A unifying model of the role of the infralimbic cortex in extinction and habits

被引：62

作者：

Barker, Jacqueline M. ^{[1
]}

Taylor, Jane R. ^{[2
]}

Chandler, L. Judson ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

[2] Yale Univ, Dept Psychiat, Sch Med, New Haven, CT 06519 USA

来源：

LEARNING & MEMORY | 2014年 / 21卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MEDIAL PREFRONTAL CORTEX; FEAR EXTINCTION; CONDITIONED FEAR; NUCLEUS-ACCUMBENS; INDIVIDUAL-DIFFERENCES; COCAINE SEEKING; DOPAMINE NEUROTRANSMISSION; BIDIRECTIONAL MODULATION; NEUROIMAGING EVIDENCE; AMPHETAMINE EXPOSURE;

D O I：

10.1101/lm.035501.114

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize that IL suppresses behavior as part of a "stop" network. However, this framework is at odds with IL function in habitual behavior in which the IL has been shown to be required for the expression and acquisition of ongoing habitual behavior. Here, we will review the current state of knowledge of IL anatomy and function in behavioral flexibility and provide a testable framework for a single IL mechanism underlying its function in both extinction and habit learning.

引用

页码：441 / 448

页数：8

共 92 条

[11] TOPOGRAPHY OF PROJECTIONS FROM THE MEDIAL PREFRONTAL CORTEX TO THE AMYGDALA IN THE RAT [J].

CASSELL, MD ;

WRIGHT, DJ .

BRAIN RESEARCH BULLETIN, 1986, 17 (03) :321-333

[12] Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats [J].

Castillo-Gomez, Esther ;

Gomez-Climent, Maria Angeles ;

Varea, Emilio ;

Guirado, Ramon ;

Blasco-Ibanez, Jose Miguel ;

Crespo, Carlos ;

Martinez-Guijarro, Francisco Jose ;

Nacher, Juan .

EXPERIMENTAL NEUROLOGY, 2008, 214 (01) :97-111

[13]

Chudasama Y, 2003, J NEUROSCI, V23, P8771

[14] Fronto-striatal functional connectivity during response inhibition in alcohol dependence [J].

Courtney, Kelly E. ;

Ghahremani, Dara G. ;

Ray, Lara A. .

ADDICTION BIOLOGY, 2013, 18 (03) :593-604

[15] Inactivation of the infralimbic prefrontal cortex reinstates goal-directed responding in overtrained rats [J].

Coutureau, E ;

Killcross, S .

BEHAVIOURAL BRAIN RESEARCH, 2003, 146 (1-2) :167-174

[16] Corticostriatal Connectivity Underlies Individual Differences in the Balance between Habitual and Goal-Directed Action Control [J].

de Wit, Sanne ;

Watson, Poppy ;

Harsay, Helga A. ;

Cohen, Michael X. ;

van de Vijver, Irene ;

Ridderinkhof, K. Richard .

JOURNAL OF NEUROSCIENCE, 2012, 32 (35) :12066-12075

[17] Differential Engagement of the Ventromedial Prefrontal Cortex by Goal-Directed and Habitual Behavior toward Food Pictures in Humans [J].

de Wit, Sanne ;

Corlett, Philip R. ;

Aitken, Mike R. ;

Dickinson, Anthony ;

Fletcher, Paul C. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (36) :11330-11338

[18]

Delamater AR, 2013, NEUROBIOL LEARN MEM

[19] Alcohol seeking by rats: Action or habit? [J].

Dickinson, A ;

Wood, N ;

Smith, JW .

QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 2002, 55 (04) :331-348

[20] ACTIONS AND HABITS - THE DEVELOPMENT OF BEHAVIORAL AUTONOMY [J].

DICKINSON, A .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1985, 308 (1135) :67-78

← 1 2 3 4 5 6 7 8 9 10 →