A unifying model of the role of the infralimbic cortex in extinction and habits

被引：62

作者：

Barker, Jacqueline M. ^{[1
]}

Taylor, Jane R. ^{[2
]}

Chandler, L. Judson ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

[2] Yale Univ, Dept Psychiat, Sch Med, New Haven, CT 06519 USA

来源：

LEARNING & MEMORY | 2014年 / 21卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MEDIAL PREFRONTAL CORTEX; FEAR EXTINCTION; CONDITIONED FEAR; NUCLEUS-ACCUMBENS; INDIVIDUAL-DIFFERENCES; COCAINE SEEKING; DOPAMINE NEUROTRANSMISSION; BIDIRECTIONAL MODULATION; NEUROIMAGING EVIDENCE; AMPHETAMINE EXPOSURE;

D O I：

10.1101/lm.035501.114

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize that IL suppresses behavior as part of a "stop" network. However, this framework is at odds with IL function in habitual behavior in which the IL has been shown to be required for the expression and acquisition of ongoing habitual behavior. Here, we will review the current state of knowledge of IL anatomy and function in behavioral flexibility and provide a testable framework for a single IL mechanism underlying its function in both extinction and habit learning.

引用

页码：441 / 448

页数：8

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