Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort

被引：62

作者：

Tikk, K. ^{[1
]}

Sookthai, D. ^{[1
]}

Johnson, T. ^{[1
]}

Rinaldi, S. ^{[2
]}

Romieu, I. ^{[2
]}

Tjonneland, A. ^{[3
]}

Olsen, A. ^{[3
]}

Overvad, K. ^{[4
]}

Clavel-Chapelon, F. ^{[5
,6
,7
]}

Baglietto, L. ^{[8
,9
]}

Boeing, H. ^{[10
]}

Trichopoulou, A. ^{[11
,12
]}

Lagiou, P. ^{[11
,13
,14
]}

Trichopoulos, D. ^{[12
,13
,14
]}

Palli, D. ^{[15
]}

Pala, V. ^{[16
]}

Tumino, R. ^{[17
,18
]}

Rosso, S. ^{[19
]}

Panico, S. ^{[20
]}

Agudo, A. ^{[21
]}

Menendez, V. ^{[22
]}

Sanchez, M. -J. ^{[23
,24
]}

Amiano, P. ^{[24
,25
]}

Huerta Castano, J. M. ^{[24
,26
]}

Ardanaz, E. ^{[24
,27
]}

Bueno-de-Mesquita, H. B. ^{[28
,29
,30
]}

Monninkhof, E. ^{[31
]}

Onland-Moret, C. ^{[31
]}

Andersson, A. ^{[32
]}

Sund, M. ^{[33
]}

Weiderpass, E. ^{[34
,35
,36
,37
]}

Khaw, K. -T. ^{[38
]}

Key, T. J. ^{[39
]}

Travis, R. C. ^{[39
]}

Gunter, M. J. ^{[30
]}

Riboli, E. ^{[30
]}

Dossus, L. ^{[5
,6
,7
]}

Kaaks, R. ^{[1
]}

机构：

[1] German Canc Res Ctr DKFZ Heidelberg, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Int Agcy Res Canc, Sect Nutr & Metab, F-69372 Lyon, France

[3] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[4] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[5] INSERM, Nutr Hormones & Womens Hlth Team, Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France

[6] Univ Paris 11, UMRS, Villejuif, France

[7] IGR, Villejuif, France

[8] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[9] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[10] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Potsdam, Nuthetal, Germany

[11] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[12] Hellen Hlth Fdn, Athens, Greece

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Acad Athens, Bur Epidemiol Res, Athens, Greece

[15] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[16] Natl Tumor Inst IRCCS, Epidemiol & Prevent Unit, Milan, Italy

[17] Civ MP Arezzo Hosp ASP, Canc Registry, Ragusa, Italy

[18] Civ MP Arezzo Hosp ASP, Histopathol Unit, Ragusa, Italy

[19] Ctr Epidemiol & Prevent Oncol Piedmont, Piedmont Canc Registry, Turin, Italy

[20] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[21] IDIBELL, Catalan Inst Oncol ICO, Unit Nutr Environm & Canc, Barcelona, Spain

[22] Publ Hlth Directorate, Asturias, Spain

[23] Andalusian Sch Publ Hlth, Granada Canc Registry, Granada, Spain

[24] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain

[25] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[26] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[27] Navarre Publ Hlth Inst, Pamplona, Spain

[28] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[29] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[30] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[31] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[32] Umea Univ, Dept Radiat Sci, Umea, Sweden

[33] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[34] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway

[35] Canc Registry Norway, Dept Res, Oslo, Norway

[36] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[37] Soc Publ Hlth, Helsinki, Finland

[38] Univ Cambridge, Sch Clin Med, Cambridge, England

[39] Univ Oxford, Canc Epidemiol Unit, Oxford, England

来源：

ANNALS OF ONCOLOGY | 2014年 / 25卷 / 07期

基金：

英国医学研究理事会;

关键词：

breast cancer; prolactin levels; hormone replacement therapy; estrogen receptor; progesterone receptor; prospective cohort; PLASMA PROLACTIN; RECEPTOR; HORMONES; REPRODUCIBILITY;

D O I：

10.1093/annonc/mdu150

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Experimental and epidemiological evidence suggests that prolactin might play a role in the etiology of breast cancer. We analyzed the relationship of prediagnostic circulating prolactin levels with the risk of breast cancer by menopausal status, use of postmenopausal hormone replacement therapy (HRT) at blood donation, and by estrogen and progesterone receptor status of the breast tumors. Conditional logistic regression was used to analyze the data from a case-control study nested within the prospective European EPIC cohort, including 2250 invasive breast cancer and their matched control subjects. Statistically significant heterogeneity in the association of prolactin levels with breast cancer risk between women who were either pre- or postmenopausal at the time of blood donation was observed (P-het = 0.04). Higher serum levels of prolactin were associated with significant increase in the risk of breast cancer among postmenopausal women [odds ratio (OR)(Q4-Q1) = 1.29 (95% confidence interval, CI, 1.05-1.58), P-trend = 0.09]; however, this increase in risk seemed to be confined to women who used postmenopausal HRT at blood donation [ORQ4-Q1 = 1.45 (95% CI 1.08-1.95), P-trend = 0.01], whereas no statistically significant association was found for the non-users of HRT [ORQ4-Q1 = 1.11 (95%CI 0.83-1.49), P-trend = 0.80] (P-het = 0.08). Among premenopausal women, a statistically non-significant inverse association was observed [ORQ4-Q1 = 0.70 (95% CI 0.48-1.03), P-trend = 0.16]. There was no heterogeneity in the prolactin-breast cancer association by hormone receptor status of the tumor. Our study indicates that higher circulating levels of prolactin among the postmenopausal HRT users at baseline may be associated with increased breast cancer risk.

引用

页码：1422 / 1428

页数：7

共 50 条

[21] Serum sex hormone levels in pre- and postmenopausal breast cancer patients [J].

Ho, C. C. K. ;

Rohaizak, M. ;

Zulkifli, S. Z. ;

Siti-Aishah, M. A. ;

Nor-Aini, U. ;

Sharifah-Noor-Akmal, S. H. .

SINGAPORE MEDICAL JOURNAL, 2009, 50 (05) :513-518

[22] Relationship between plasma progesterone, estradiol and prolactin concentrations and breast cancer in pre and postmenopausal women [J].

Raheem, S. N. A. ;

Atoum, M. ;

Al-Hourani, H. ;

Rasheed, M. ;

Nimer, N. ;

Almuhrib, T. .

NEOPLASMA, 2010, 57 (01) :74-78

[23] Adult weight change and the risk of pre- and postmenopausal breast cancer in the Chinese Wuxi Exposure and Breast Cancer Study [J].

Shang Cao ;

Jinyi Zhou ;

Zheng Zhu ;

Feiran Wei ;

Wei Li ;

Shurong Lu ;

Jian Su ;

Hao Yu ;

Wencong Du ;

Lan Cui ;

Pingmin Wei ;

Ming Wu .

Breast Cancer Research and Treatment, 2019, 173 :647-655

[24] Adult weight change and the risk of pre- and postmenopausal breast cancer in the Chinese Wuxi Exposure and Breast Cancer Study [J].

Cao, Shang ;

Zhou, Jinyi ;

Zhu, Zheng ;

Wei, Feiran ;

Li, Wei ;

Lu, Shurong ;

Su, Jian ;

Yu, Hao ;

Du, Wencong ;

Cui, Lan ;

Wei, Pingmin ;

Wu, Ming .

BREAST CANCER RESEARCH AND TREATMENT, 2019, 173 (03) :647-655

[25] Prolactin serum levels and breast cancer: relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case–control study from Poland [J].

J M Faupel-Badger ;

M E Sherman ;

M Garcia-Closas ;

M M Gaudet ;

R T Falk ;

A Andaya ;

R M Pfeiffer ;

X R Yang ;

J Lissowska ;

L A Brinton ;

B Peplonska ;

B K Vonderhaar ;

J D Figueroa .

British Journal of Cancer, 2010, 103 :1097-1102

[26] Body weight and risk of molecular breast cancer subtypes among postmenopausal Mediterranean women [J].

Crispo, A. ;

Montella, M. ;

Buono, G. ;

Grimaldi, M. ;

D'Aiuto, M. ;

Capasso, I. ;

Esposito, E. ;

Amore, A. ;

Nocerino, F. ;

Augustin, L. S. A. ;

Giudice, A. ;

Di Bonito, M. ;

Giuliano, M. ;

Forestieri, V. ;

De laurentiis, M. ;

Rinaldo, M. ;

Ciliberto, G. ;

De Placido, S. ;

Arpino, G. .

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2016, 64 (01) :15-20

[27] Associations of anthropometric measures on breast cancer risk in pre- and postmenopausal women—a case-control study [J].

Renata Pacholczak ;

Wiesława Klimek-Piotrowska ;

Piotr Kuszmiersz .

Journal of Physiological Anthropology, 35

[28] Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women:: A study within the EPIC cohort [J].

Rinaldi, S ;

Key, TJ ;

Peeters, PHM ;

Lahmann, PH ;

Lukanova, A ;

Dossus, L ;

Biessy, C ;

Vineis, P ;

Sacerdote, C ;

Berrino, F ;

Panico, S ;

Tumino, R ;

Palli, D ;

Nagel, G ;

Linseisen, J ;

Boeing, H ;

Roddam, A ;

Bingham, S ;

Khaw, KT ;

Chloptios, J ;

Trichopoulou, A ;

Trichopoulos, D ;

Tehard, B ;

Clavel-Chapelon, F ;

Gonzalez, CA ;

Larrañaga, N ;

Barricarte, A ;

Quiros, JR ;

Chirlaque, MD ;

Martinez, C ;

Monninkhof, E ;

Grobbee, DE ;

Bueno-De-Mesquita, HB ;

Ferrari, P ;

Slimani, N ;

Riboli, E ;

Kaaks, R .

INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (11) :2832-2839

[29] Circulating Estrogen Metabolites and Risk of Breast Cancer among Postmenopausal Women in the Nurses' Health Study [J].

Brantley, Kristen D. ;

Ziegler, Regina G. ;

Craft, Neal E. ;

Hankinson, Susan E. ;

Eliassen, A. Heather .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2025, 34 (03) :375-384

[30] Correlation between iron metabolism and development of breast cancer in pre- and postmenopausal women [J].

Kubiak, Tomasz .

MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY, 2013, 12 (04) :339-342

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