Synthetic approaches to the 2012 new drugs

被引：38
作者：
Ding, Hong X. [1 ]
Leverett, Carolyn A. [2 ]
Kyne, Robert E., Jr. [2 ]
Liu, Kevin K. -C. [3 ]
Sakya, Subas M. [4 ]
Flick, Andrew C. [2 ]
O'Donnell, Christopher J. [2 ]
机构：
[1] PharmaPhase Co Ltd, Beijing 100193, Peoples R China
[2] Pfizer Worldwide Res & Dev, Groton Labs, Groton, CT 06340 USA
[3] Lilly China Res & Dev Ctr, Shanghai 201203, Peoples R China
[4] BioDuro Co Ltd, Shanghai 200131, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2014年 / 22卷 / 07期
关键词：
Synthesis; New drug molecules; New chemical entities; Medicine; Therapeutic agents; CHRONIC MYELOID-LEUKEMIA; ANTIINFLAMMATORY AGENT 3-FORMYLAMINO-7-METHYLSULFONYLAMINO-6-PHENOXY-4H-1-BENZOPYRAN-4-ONE; DIHYDROOROTATE DEHYDROGENASE; ANTITUMOR ALKALOIDS; PASIREOTIDE SOM230; INGENOL ESTERS; IN-VITRO; INHIBITOR; POTENT; DISCOVERY;
D O I：
10.1016/j.bmc.2014.02.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New drugs introduced to the market every year represent a privileged structure for a particular biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of twenty-six NCEs that were launched or approved worldwide in 2012 and two additional drugs which were launched at the end of 2011. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：2005 / 2032
页数：28
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