Copy number variation analysis reveals variants associated with milk production traits in dairy goats

被引：14
|
作者：
Kang, Xiaolong [1 ,2 ]
Li, Mingxun [1 ,3 ]
Liu, Mei [4 ]
Liu, Shuli [1 ,5 ]
Pan, Michael G. [1 ]
Wiggans, George R. [6 ]
Rosen, Benjamin D. [1 ]
Liu, George E. [1 ]
机构：
[1] ARS, USDA, Anim Genom & Improvement Lab, BARC, Beltsville, MD USA
[2] Ningxia Univ, Coll Agr, Yinchuan, Ningxia, Peoples R China
[3] Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China
[4] Hunan Agr Univ, Coll Anim Sci & Technol, Anim Nutr Genome & Germplasm Innovat Res Ctr, Changsha, Peoples R China
[5] China Agr Univ, Coll Anim Sci & Technol, Beijing, Peoples R China
[6] Council Dairy Cattle Breeding, Bowie, MD USA
来源：
GENOMICS | 2020年 / 112卷 / 06期
基金：
美国食品与农业研究所;
关键词：
Dairy goat; Copy number variation (CNV); Milk production traits; EXTRACELLULAR-MATRIX; PLASMA PROTEIN-A2; GENE; PROLACTIN; PREGNANCY;
D O I：
10.1016/j.ygeno.2020.09.007
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Copy number variation (CNV) is a major type of genomic structural variation. We investigated their impacts on goat dairy traits using the CaprineSNP50 array. From 120 samples of five dairy goat breeds, we totally identified 42 CNVs ranging from 56,044 bp to 4,337,625 bp. We found significant associations between two CNVs (CNV5 and CNV25) and two milk production traits (mean of milk fat yield and mean of milk protein yield) after false discovery rate (FDR) correction (P < 0.05). CNV5 overlaps the ADAMTS20 gene, which is involved in the differentiation of mammary cell and plays a crucial role in lactogenic activity of bovine mammary epithelial cells. CNV25 overlaps with PAPPA2, which has been found to be associated with bovine reproduction and milk production traits. Our results revealed that CNVs overlapped with ADAMTS20 and PAPPA2 could be involved in goat dairy traits and function as candidate markers for further genetic selection.
引用
收藏
页码：4934 / 4937
页数：4
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