Near-infrared Raman spectrometer systems for human tissue studies

被引：103

作者：

Brennan, JF ^{[1
]}

Wang, Y ^{[1
]}

Dasari, RR ^{[1
]}

Feld, MS ^{[1
]}

机构：

[1] MIT,GEORGE R HARRISON SPECT LAB,LASER BIOMED RES CTR,CAMBRIDGE,MA 02139

来源：

APPLIED SPECTROSCOPY | 1997年 / 51卷 / 02期

关键词：

Raman spectroscopy; optical-fiber sampling; biomedical spectroscopy; CCD detectors; instrumentation; calibration techniques;

D O I：

10.1366/0003702971940134

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

We have built two types of instruments for near-infrared Raman spectroscopy studies of human tissues, one for laboratory measurements and one for clinical use. The laboratory systems are designed to collect the highest quality spectra possible and allow different excitation/collection wavelengths to be studied. The clinical systems are designed to collect spectra via optical fibers within a few seconds and to be mobile and hospital-compatible. These systems are capable of detecting weak near-infrared Raman bands hidden in large background signals. Calibration and background subtraction procedures are described, and system performance is evaluated.

引用

页码：201 / 208

页数：8

共 40 条

[21] LASER RAMAN-SPECTRUM OF CALCIFIED HUMAN AORTA [J].

KLUG, DD ;

SINGLETON, DL ;

WALLEY, VM .

LASERS IN SURGERY AND MEDICINE, 1992, 12 (01) :13-17

[22]

KRAMER JR, 1995, P SOC PHOTO-OPT INS, V2395, P376

[23] APPLICATION OF LEGENDRE POLYNOMIALS TO THE ELIMINATION OF BASELINE VARIATION IN BIOLOGICAL FT-IR SPECTRA [J].

LIPKUS, AH .

APPLIED SPECTROSCOPY, 1988, 42 (03) :395-400

[24]

Liu C. H., 1992, Lasers in the Life Sciences, V4, P257

[25] A NEW BASE-LINE CORRECTION ALGORITHM USING OBJECTIVE CRITERIA [J].

LIU, JW ;

KOENIG, JL .

APPLIED SPECTROSCOPY, 1987, 41 (03) :447-449

[26] Histochemical analysis of biological tissues using Raman spectroscopy [J].

Manoharan, R ;

Wang, Y ;

Feld, MS .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 1996, 52 (02) :215-249

[27] QUANTITATIVE HISTOCHEMICAL ANALYSIS OF HUMAN ARTERY USING RAMAN-SPECTROSCOPY [J].

MANOHARAN, R ;

BARAGA, JJ ;

FELD, MS ;

RAVA, RP .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1992, 16 (02) :211-233

[28]

MCCREERY RL, 1996, IN PRESS MODERN TECH, pCH3

[29] NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPIC STUDY OF HUMAN BRAIN-TISSUES AND TUMORS [J].

MIZUNO, A ;

KITAJIMA, H ;

KAWAUCHI, K ;

MURAISHI, S ;

OZAKI, Y .

JOURNAL OF RAMAN SPECTROSCOPY, 1994, 25 (01) :25-29

[30] ELIMINATION OF BACKGROUND IN FIBEROPTIC RAMAN MEASUREMENTS [J].

MYRICK, ML ;

ANGEL, SM .

APPLIED SPECTROSCOPY, 1990, 44 (04) :565-570

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