Management of Chronic Strongyloidiasis in Immigrants and Refugees: Is Serologic Testing Useful?

被引：58

作者：

Biggs, Beverley-Ann ^{[1
]}

Caruana, Sonia ^{[1
]}

Mihrshahi, Seema ^{[1
]}

Jolley, Damien ^{[2
]}

Leydon, Jenne ^{[3
]}

Chea, Ley ^{[4
]}

Nuon, Sophy ^{[5
]}

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3050, Australia

[2] Monash Inst Hlth Serv Res, Clayton, Vic 3168, Australia

[3] Victorian Infect Dis Reference Lab, Serol Lab, Melbourne, Vic 3051, Australia

[4] Windsor Med Ctr, Springvale, Vic 3171, Australia

[5] Med Clin, Springvale, Vic 3071, Australia

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 80卷 / 05期

关键词：

STERCORALIS INFECTION; EOSINOPHIL COUNT; IVERMECTIN; ALBENDAZOLE; DIAGNOSIS; THIABENDAZOLE; SENSITIVITY; AUSTRALIA; EFFICACY; TRIAL;

D O I：

10.4269/ajtmh.2009.80.788

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We assessed the usefulness of serologic testing in monitoring strongyloidiasis in immigrants after treatment with two doses of ivermectin. An observational study was conducted in a group of Cambodian immigrants residing in Melbourne who were treated for strongyloidiasis and followed-up in a general practice setting. Two doses of ivermectin (200 mu g/kg) were administered orally. Periodic serologic enzyme-linked immunosorbent assay testing was undertaken for up to 30 months after treatment. Antibody titers for Strongyloides sp. decreased in 95% (38 of 40) of the patients, 47.5% (19 of 40) had a decrease in optical density to less than 0.5, and 65 % (26 of 40) reached levels consistent with a cure during the follow-up period. Serologic testing for Strongyloides sp. is a useful too] for monitoring a decrease in antibody levels after effective treatment. This testing should be carried out 6-12 months after treatment to ensure a sustained downward trend suggestive of cure.

引用

页码：788 / 791

页数：4

共 31 条

[1]

Adenusi A. A., 2003, African Journal of Biotechnology, V2, P465

[2]

BIGGS B, 2003, 2 NAT WORKSH STRONG

[3] Undiagnosed and potentially lethal parasite infections among immigrants and refugees in Australia [J].

Caruana, Sonia R. ;

Kelly, Heath A. ;

Ngeow, Joanne Y. Y. ;

Ryan, Norbert J. ;

Bennett, Catherine M. ;

Chea, Ley ;

Nuon, Sophy ;

Bak, Narin ;

Skull, Susan A. ;

Biggs, Beverley-Ann .

JOURNAL OF TRAVEL MEDICINE, 2006, 13 (04) :233-239

[4] TREATMENT OF STRONGYLOIDES-STERCORALIS INFECTION WITH IVERMECTIN COMPARED WITH ALBENDAZOLE - RESULTS OF AN OPEN STUDY OF 60 CASES [J].

DATRY, A ;

HILMARSDOTTIR, I ;

MAYORGASAGASTUME, R ;

LYAGOUBI, M ;

GAXOTTE, P ;

BILIGUI, S ;

CHODAKEWITZ, J ;

NEU, D ;

DANIS, M ;

GENTILINI, M .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (03) :344-345

[5] Chronic Strongyloides stercoralis infection in Laotian immigrants and refugees 7-20 years after resettlement in Australia [J].

De Silva, S ;

Saykao, P ;

Kelly, H ;

MacIntyre, CR ;

Ryan, N ;

Leydon, J ;

Biggs, BA .

EPIDEMIOLOGY AND INFECTION, 2002, 128 (03) :439-444

[6] COMPARATIVE SENSITIVITY AND SPECIFICITY OF ELISA AND IHA FOR SERODIAGNOSIS OF STRONGYLOIDIASIS WITH LARVAL ANTIGENS [J].

GAM, AA ;

NEVA, FA ;

KROTOSKI, WA .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1987, 37 (01) :157-161

[7] A RANDOMIZED TRIAL OF SINGLE-DOSE AND 2-DOSE IVERMECTIN VERSUS THIABENDAZOLE FOR TREATMENT OF STRONGYLOIDIASIS [J].

GANN, PH ;

NEVA, FA ;

GAM, AA .

JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (05) :1076-1079

[8] PROMINENCE OF IGG4 ANTIBODIES IN THE HUMAN RESPONSES TO STRONGYLOIDES-STERCORALIS INFECTION [J].

GENTA, RM ;

LILLIBRIDGE, JP .

JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (04) :692-699

[9]

Grove D.I., 1989, P175

[10]

Heukelbach J, 2004, B WORLD HEALTH ORGAN, V82, P563

← 1 2 3 4 →