Pharmacological treatment of COVID-19: an opinion paper

被引：39

作者：

Garcia-Lledo, A. ^{[1
]}

Gomez-Pavon, J. ^{[2
]}

Gonzalez del Castillo, J. ^{[3
]}

Hernandez-Sampelayo, T. ^{[4
]}

Martin-Delgado, M. C. ^{[5
]}

Martin Sanchez, F. J. ^{[6
]}

Martinez-Selles, M. ^{[7
]}

Molero Garcia, J. M. ^{[8
]}

Moreno Guillen, S. ^{[9
]}

Rodriguez-Artalejo, F. J. ^{[10
]}

Ruiz-Galiana, J. ^{[11
]}

Canton, R. ^{[12
,13
]}

De Lucas Ramos, P. ^{[14
]}

Garcia-Botella, A. ^{[15
]}

Bouza, E. ^{[16
]}

机构：

[1] Univ Alcala, Prince Asturias Hosp, Cardiol Serv, Madrid, Spain

[2] Alfonso X El Sabio Univ, Cent Hosp Red Cross, Geriatr Serv, Madrid, Spain

[3] Univ Complutense Madrid, San Carlos Univ Clin Hosp, Emergency Serv, Madrid, Spain

[4] Univ Complutense Madrid, Gregorio Maranon Gen Univ Hosp, Pediat & ACES Serv, Madrid, Spain

[5] Francisco Vitoria Univ, Torrejon Univ Hosp, Intens Med Serv, Madrid, Spain

[6] Univ Complutense Madrid, San Carlos Univ Clin Hosp, Geriatr Serv, Madrid, Spain

[7] European Univ, Gregorio Maranon Gen Univ Hosp, Cardiol Serv, Madrid, Spain

[8] Infect Dis, Family Med, Madrid, Spain

[9] Univ Alcala Henares, Ramon y Cajal Hosp, Infect Dis Serv, Madrid, Spain

[10] Autonomous Univ, Dept Publ Hlth, Madrid, Spain

[11] Ruber Int Hosp, Internal Med Serv, Madrid, Spain

[12] Ramon & Cajal Hosp, Microbiol Serv, Madrid, Spain

[13] Ramon y Cajal Inst Hlth Res IRYCIS, Spanish Network Res Infect Pathol REIPI, Madrid, Spain

[14] Univ Complutense Madrid, Gregorio Maranon Gen Univ Hosp, Pneumol Serv, Madrid, Spain

[15] Univ Complutense Madrid, San Carlos Univ Clin Hosp, Gen Surg Serv, Madrid, Spain

[16] Univ Complutense Madrid, Gregorio Maranon Gen Univ Hosp, Clin Microbiol & Infect Dis Serv, Community Madrid, Madrid, Spain

来源：

REVISTA ESPANOLA DE QUIMIOTERAPIA | 2022年 / 35卷 / 02期

关键词：

COVID; 19; SARS; CoV2; treatment; Remdesivir; Favipiravir; Molnupiravir; PF-07321332; Paxlovid; convalescent plasma; Sotrovimab; Banlanivimab; Etesevimab; Casirivimab; Imdevinab; AZD7442; Ciganilmab; Tixagevimab; Evusheld; BRII-196; BRII-198; Dexamethasone; Corticosteroids; Tocilizumab; Sarilumab; Anakinra; Canakinumab; Baricitinib; Tofacitinib; Ruxolitinib; Adalimumab; Certolizumab; Infliximab; Etanercept; Golimumab; Itolizumab; Ravulizumab; Lemilumab; Ivermectin; Colchicine; Vitamin D; Metformin; Fluvoxamine; Azithromycin; Hydroxychloroquine; Lopinavir/; Ritonavir; OPEN-LABEL; TOCILIZUMAB; FAVIPIRAVIR; SARS-COV-2; REMDESIVIR; BLOCKADE; ANAKINRA; MODERATE; TRIAL;

D O I：

10.37201/req/158.2021

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The precocity and efficacy of the vaccines developed so far against COVID-19 has been the most significant and saving advance against the pandemic. The development of vaccines has not prevented, during the whole period of the pandemic, the constant search for therapeutic medicines, both among existing drugs with different indications and in the development of new drugs. The Scientific Committee of the COVID-19 of the Illustrious College of Physicians of Madrid wanted to offer an early, simplified and critical approach to these new drugs, to new developments in immunotherapy and to what has been learned from the immune response modulators already known and which have proven effective against the virus, in order to help understand the current situation.

引用

页码：115 / 130

页数：16

共 142 条

[31] RETRACTED: Safety and efficacy of favipiravir versus hydroxychloroquine in management of COVID-19: A randomised controlled trial (Retracted Article) [J].

Dabbous, Hany M. ;

El-Sayed, Manal H. ;

El Assal, Gihan ;

Elghazaly, Hesham ;

Ebeid, Fatma F. S. ;

Sherief, Ahmed F. ;

Elgaafary, Maha ;

Fawzy, Ehab ;

Hassany, Sahar M. ;

Riad, Ahmed R. ;

TagelDin, Mohamed A. .

SCIENTIFIC REPORTS, 2021, 11 (01)

[32] COVID-19 infection in children and adolescents with cancer in Madrid [J].

de Rojas, Teresa ;

Perez-Martinez, Antonio ;

Cela, Elena ;

Baragano, Marta ;

Galan, Victor ;

Mata, Cristina ;

Pereto, Alba ;

Madero, Luis .

PEDIATRIC BLOOD & CANCER, 2020, 67 (07)

[33] Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19 A Randomized Clinical Trial [J].

Dequin, Pierre-Francois ;

Heming, Nicholas ;

Meziani, Ferhat ;

Plantefeve, Gaetan ;

Voiriot, Guillaume ;

Badie, Julio ;

Francois, Bruno ;

Aubron, Cecile ;

Ricard, Jean-Damien ;

Ehrmann, Stephan ;

Jouan, Youenn ;

Guillon, Antoine ;

Leclerc, Marie ;

Coffre, Carine ;

Bourgoin, Helene ;

Lengelle, Celine ;

Caille-Fenerol, Caroline ;

Tavernier, Elsa ;

Zohar, Sarah ;

Giraudeau, Bruno ;

Annane, Djillali ;

Le Gouge, Amelie .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 324 (13) :1298-1306

[34] Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail [J].

Dong, Jinhui ;

Zost, Seth J. ;

Greaney, Allison J. ;

Starr, Tyler N. ;

Dingens, Adam S. ;

Chen, Elaine C. ;

Chen, Rita E. ;

Case, James Brett ;

Sutton, Rachel E. ;

Gilchuk, Pavlo ;

Rodriguez, Jessica ;

Armstrong, Erica ;

Gainza, Christopher ;

Nargi, Rachel S. ;

Binshtein, Elad ;

Xie, Xuping ;

Zhang, Xianwen ;

Shi, Pei-Yong ;

Logue, James ;

Weston, Stuart ;

McGrath, Marisa E. ;

Frieman, Matthew B. ;

Brady, Tyler ;

Tuffy, Kevin M. ;

Bright, Helen ;

Loo, Yueh-Ming ;

McTamney, Patrick M. ;

Esser, Mark T. ;

Carnahan, Robert H. ;

Diamond, Michael S. ;

Bloom, Jesse D. ;

Crowe, James E., Jr. .

NATURE MICROBIOLOGY, 2021, 6 (10) :1233-+

[35] Epidemiology of COVID-19 Among Children in China [J].

Dong, Yuanyuan ;

Mo, Xi ;

Hu, Yabin ;

Qi, Xin ;

Jiang, Fan ;

Jiang, Zhongyi ;

Tong, Shilu .

PEDIATRICS, 2020, 145 (06)

[36] Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19 [J].

Dougan, M. ;

Nirula, A. ;

Azizad, M. ;

Mocherla, B. ;

Gottlieb, R. L. ;

Chen, P. ;

Hebert, C. ;

Perry, R. ;

Boscia, J. ;

Heller, B. ;

Morris, J. ;

Crystal, C. ;

Igbinadolor, A. ;

Huhn, G. ;

Cardona, J. ;

Shawa, I ;

Kumar, P. ;

Adams, A. C. ;

Van Naarden, J. ;

Custer, K. L. ;

Durante, M. ;

Oakley, G. ;

Schade, A. E. ;

Holzer, T. R. ;

Ebert, P. J. ;

Higgs, R. E. ;

Kallewaard, N. L. ;

Sabo, J. ;

Patel, D. R. ;

Dabora, M. C. ;

Klekotka, P. ;

Shen, L. ;

Skovronsky, D. M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (15) :1382-1392

[37] Covid-19: Hospital may cease giving patient ivermectin, US court rules, as prescriptions soar [J].

Dyer, Owen .

BMJ-BRITISH MEDICAL JOURNAL, 2021, 374 :n2228

[38] Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study [J].

Entrenas Castillo, Marta ;

Entrenas Costa, Luis Manuel ;

Vaquero Barrios, Jose Manuel ;

Alcala Diaz, Juan Francisco ;

Lopez Miranda, Jose ;

Bouillon, Roger ;

Quesada Gomez, Jose Manuel .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2020, 203

[39]

Euroepan Medicines Agency, 2021, BAMLANIVIMAB ETESEVI

[40]

European Medicines Agency, 2021, EMA issues advice on use of Lagevrio (molnupiravir) for the treatment of COVID-19

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