Pharmacological treatment of COVID-19: an opinion paper

被引：39

作者：

Garcia-Lledo, A. ^{[1
]}

Gomez-Pavon, J. ^{[2
]}

Gonzalez del Castillo, J. ^{[3
]}

Hernandez-Sampelayo, T. ^{[4
]}

Martin-Delgado, M. C. ^{[5
]}

Martin Sanchez, F. J. ^{[6
]}

Martinez-Selles, M. ^{[7
]}

Molero Garcia, J. M. ^{[8
]}

Moreno Guillen, S. ^{[9
]}

Rodriguez-Artalejo, F. J. ^{[10
]}

Ruiz-Galiana, J. ^{[11
]}

Canton, R. ^{[12
,13
]}

De Lucas Ramos, P. ^{[14
]}

Garcia-Botella, A. ^{[15
]}

Bouza, E. ^{[16
]}

机构：

[1] Univ Alcala, Prince Asturias Hosp, Cardiol Serv, Madrid, Spain

[2] Alfonso X El Sabio Univ, Cent Hosp Red Cross, Geriatr Serv, Madrid, Spain

[3] Univ Complutense Madrid, San Carlos Univ Clin Hosp, Emergency Serv, Madrid, Spain

[4] Univ Complutense Madrid, Gregorio Maranon Gen Univ Hosp, Pediat & ACES Serv, Madrid, Spain

[5] Francisco Vitoria Univ, Torrejon Univ Hosp, Intens Med Serv, Madrid, Spain

[6] Univ Complutense Madrid, San Carlos Univ Clin Hosp, Geriatr Serv, Madrid, Spain

[7] European Univ, Gregorio Maranon Gen Univ Hosp, Cardiol Serv, Madrid, Spain

[8] Infect Dis, Family Med, Madrid, Spain

[9] Univ Alcala Henares, Ramon y Cajal Hosp, Infect Dis Serv, Madrid, Spain

[10] Autonomous Univ, Dept Publ Hlth, Madrid, Spain

[11] Ruber Int Hosp, Internal Med Serv, Madrid, Spain

[12] Ramon & Cajal Hosp, Microbiol Serv, Madrid, Spain

[13] Ramon y Cajal Inst Hlth Res IRYCIS, Spanish Network Res Infect Pathol REIPI, Madrid, Spain

[14] Univ Complutense Madrid, Gregorio Maranon Gen Univ Hosp, Pneumol Serv, Madrid, Spain

[15] Univ Complutense Madrid, San Carlos Univ Clin Hosp, Gen Surg Serv, Madrid, Spain

[16] Univ Complutense Madrid, Gregorio Maranon Gen Univ Hosp, Clin Microbiol & Infect Dis Serv, Community Madrid, Madrid, Spain

来源：

REVISTA ESPANOLA DE QUIMIOTERAPIA | 2022年 / 35卷 / 02期

关键词：

COVID; 19; SARS; CoV2; treatment; Remdesivir; Favipiravir; Molnupiravir; PF-07321332; Paxlovid; convalescent plasma; Sotrovimab; Banlanivimab; Etesevimab; Casirivimab; Imdevinab; AZD7442; Ciganilmab; Tixagevimab; Evusheld; BRII-196; BRII-198; Dexamethasone; Corticosteroids; Tocilizumab; Sarilumab; Anakinra; Canakinumab; Baricitinib; Tofacitinib; Ruxolitinib; Adalimumab; Certolizumab; Infliximab; Etanercept; Golimumab; Itolizumab; Ravulizumab; Lemilumab; Ivermectin; Colchicine; Vitamin D; Metformin; Fluvoxamine; Azithromycin; Hydroxychloroquine; Lopinavir/; Ritonavir; OPEN-LABEL; TOCILIZUMAB; FAVIPIRAVIR; SARS-COV-2; REMDESIVIR; BLOCKADE; ANAKINRA; MODERATE; TRIAL;

D O I：

10.37201/req/158.2021

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The precocity and efficacy of the vaccines developed so far against COVID-19 has been the most significant and saving advance against the pandemic. The development of vaccines has not prevented, during the whole period of the pandemic, the constant search for therapeutic medicines, both among existing drugs with different indications and in the development of new drugs. The Scientific Committee of the COVID-19 of the Illustrious College of Physicians of Madrid wanted to offer an early, simplified and critical approach to these new drugs, to new developments in immunotherapy and to what has been learned from the immune response modulators already known and which have proven effective against the virus, in order to help understand the current situation.

引用

页码：115 / 130

页数：16

共 142 条

[1] RETRACTED: Remdesivir Efficacy in COVID-19 Treatment: A Randomized Controlled Trial (Retracted Article) [J].

Abd-Elsalam, Sherief ;

Salama, Marwa ;

Soliman, Shaimaa ;

Naguib, Ahmed Mohamed ;

Ibrahim, Ibrahim S. ;

Torky, Mohamed ;

Abd El Ghafar, Mohamed Samir ;

Abdul-Baki, Enas Abdul-Raouf M. ;

Elhendawy, Mohammed .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2022, 106 (03) :886-890

[2] The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model [J].

Abdelnabi, Rana ;

Foo, Caroline S. ;

Kaptein, Suzanne J. F. ;

Zhang, Xin ;

Do, Thuc Nguyen Dan ;

Langendries, Lana ;

Vangeel, Laura ;

Breuer, Judith ;

Pang, Juanita ;

Williams, Rachel ;

Vergote, Valentijn ;

Heylen, Elisabeth ;

Leyssen, Pieter ;

Dallmeier, Kai ;

Coelmont, Lotte ;

Chatterjee, Arnab K. ;

Mols, Raf ;

Augustijns, Patrick ;

De Jonghe, Steven ;

Jochmans, Dirk ;

Weynand, Birgit ;

Neyts, Johan .

EBIOMEDICINE, 2021, 72

[3] Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial [J].

Ader, Florence ;

Bouscambert-Duchamp, Maude ;

Hites, Maya ;

Peiffer-Smadja, Nathan ;

Poissy, Julien ;

Belhadi, Drifa ;

Diallo, Alpha ;

Le, Minh-Patrick ;

Peytavin, Gilles ;

Staub, Therese ;

Greil, Richard ;

Guedj, Jeremie ;

Paiva, Jose-Artur ;

Costagliola, Dominique ;

Yazdanpanah, Yazdan ;

Burdet, Charles ;

Mentre, France .

LANCET INFECTIOUS DISEASES, 2022, 22 (02) :209-221

[4] Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial) [J].

Agarwal, Anup ;

Mukherjee, Aparna ;

Kumar, Gunjan ;

Chatterjee, Pranab ;

Bhatnagar, Tarun ;

Malhotra, Pankaj .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 371

[5] Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine [J].

Ahlqvist, Grace P. ;

McGeough, Catherine P. ;

Senanayake, Chris ;

Armstrong, Joseph D. ;

Yadaw, Ajay ;

Roy, Sarabindu ;

Ahmad, Saeed ;

Snead, David R. ;

Jamison, Timothy F. .

ACS OMEGA, 2021, 6 (15) :10396-10402

[6] Efficacy and Safety of Lopinavir/Ritonavir for Treatment of COVID-19: A Systematic Review and Meta-Analysis [J].

Alhumaid, Saad ;

Al Mutair, Abbas ;

Al Alawi, Zainab ;

Alhmeed, Naif ;

Zaidi, Abdul Rehman Zia ;

Tobaiqy, Mansour .

TROPICAL MEDICINE AND INFECTIOUS DISEASE, 2020, 5 (04)

[7] Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: A retrospective cohort study [J].

Alsayed, Hawra Ali Hussain ;

Sharif-Askari, Fatemeh Saheb ;

Sharif-Askari, Narjes Saheb ;

Hussain, Ali Al Sayed ;

Hamid, Qutayba ;

Halwani, Rabih .

PLOS ONE, 2021, 16 (10)

[8] Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial [J].

Angus, Derek C. ;

Derde, Lennie ;

Al-Beidh, Farah ;

Annane, Djillali ;

Arabi, Yaseen ;

Beane, Abigail ;

Van Bentum-Puijk, Wilma ;

Berry, Lindsay ;

Bhimani, Zahra ;

Bonten, Marc ;

Bradbury, Charlotte ;

Brunkhorst, Frank ;

Buxton, Meredith ;

Buzgau, Adrian ;

Cheng, Allen C. ;

de Jong, Menno ;

Detry, Michelle ;

Estcourt, Lise ;

Fitzgerald, Mark ;

Goossens, Herman ;

Green, Cameron ;

Haniffa, Rashan ;

Higgins, Alisa M. ;

Horvat, Christopher ;

Hullegie, Sebastiaan J. ;

Kruger, Peter ;

Lamontagne, Francois ;

Lawler, Patrick R. ;

Linstrum, Kelsey ;

Litton, Edward ;

Lorenzi, Elizabeth ;

Marshall, John ;

McAuley, Daniel ;

McGlothin, Anna ;

McGuinness, Shay ;

McVerry, Bryan ;

Montgomery, Stephanie ;

Mouncey, Paul ;

Murthy, Srinivas ;

Nichol, Alistair ;

Parke, Rachael ;

Parker, Jane ;

Rowan, Kathryn ;

Sanil, Ashish ;

Santos, Marlene ;

Saunders, Christina ;

Seymour, Christopher ;

Turner, Anne ;

van de Veerdonk, Frank ;

Venkatesh, Balasubramanian .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 324 (13) :1317-1329

[9]

[Anonymous], 2021, Med Lett Drugs Ther, V63, P130

[10]

[Anonymous], 2020, MED LETT DRUGS THER, V62, P201

← 1 2 3 4 5 6 7 8 9 10 →