Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome

被引：48

作者：

Nasser, Y. ^{[1
]}

Boeckxstaens, G. E. ^{[2
]}

Wouters, M. M. ^{[2
]}

Schemann, M. ^{[3
]}

Vanner, S. ^{[1
]}

机构：

[1] Queens Univ, Kingston Gen Hosp, Gastrointestinal Dis Res Unit, Kingston, ON, Canada

[2] Univ Louvain, Translat Res Ctr Gastrointestinal Disorders, Louvain, Belgium

[3] Tech Univ Munich, Lehrstuhl Humanbiol, Freising Weihenstephan, Germany

来源：

NEUROGASTROENTEROLOGY AND MOTILITY | 2014年 / 26卷 / 04期

关键词：

histamine; IBS; mast cells; proteases; visceral hyperalgesia; DIARRHEA-PREDOMINANT IBS; CELL COUNTS CORRELATE; MAST-CELL; IMMUNE ACTIVATION; VISCERAL HYPERSENSITIVITY; ABDOMINAL-PAIN; ENTEROENDOCRINE CELLS; SEROTONIN CONTENT; COLONIC BIOPSIES; BARRIER FUNCTION;

D O I：

10.1111/nmo.12316

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundAlthough animal models of the irritable bowel syndrome (IBS) have provided important insights, there are no models that fully express the features of this complex condition. One alternative approach is the use of human intestinal biopsies obtained during endoscopic procedures to examine peripheral mechanisms in this disorder. These studies have served to confirm the existence of peripheral pathways in humans with IBS and have provided many new mechanistic insights. Two general approaches have been employed; one approach has been to examine the biological activity of mediators within the mucosal tissue of IBS patients and the other has been to examine changes in the structural properties of key signaling pathways contained within the biopsies. Using these approaches, important changes have been discovered involving the enteric nervous system and the extrinsic sensory pathway (dorsal root ganglia neurons), the immune system, and epithelial signaling in IBS patients compared to healthy subjects. PurposeThis review will systematically explore these mechanistic pathways, highlight the implications of these novel findings and discuss some of the important limitations of this approach.

引用

页码：455 / 469

页数：15

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