Lesions of dorsal striatum eliminate lose-switch responding but not mixed-response strategies in rats

被引:31
作者
Skelin, Ivan [1 ]
Hakstol, Rhys [1 ]
VanOyen, Jenn [1 ]
Mudiayi, Dominic [1 ]
Molina, Leonardo A. [1 ]
Holec, Victoria [1 ]
Hong, Nancy S. [1 ]
Euston, David R. [1 ]
McDonald, Robert J. [1 ]
Gruber, Aaron J. [1 ]
机构
[1] Univ Lethbridge, Dept Neurosci, Canadian Ctr Behav Neurosci, Lethbridge, AB T1K 3M4, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
win-stay lose-switch; dorsomedial striatum; decision-making; dorsolateral striatum; matching pennies; MEDIAL PREFRONTAL CORTEX; DORSOLATERAL STRIATUM; DORSOMEDIAL STRIATUM; DECISION-MAKING; STIMULUS-RESPONSE; BASAL GANGLIA; SIGNALS; SYSTEMS; MEMORY; TASK;
D O I
10.1111/ejn.12518
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We used focal brain lesions in rats to examine how dorsomedial (DMS) and dorsolateral (DLS) regions of the striatum differently contribute to response adaptation driven by the delivery or omission of rewards. Rats performed a binary choice task under two modes: one in which responses were rewarded on half of the trials regardless of choice; and another 'competitive' one in which only unpredictable choices were rewarded. In both modes, control animals were more likely to use a predictable lose-switch strategy than animals with lesions of either DMS or DLS. Animals with lesions of DMS presumably relied more on DLS for behavioural control, and generated repetitive responses in the first mode. These animals then shifted to a random response strategy in the competitive mode, thereby performing better than controls or animals with DLS lesions. Analysis using computational models of reinforcement learning indicated that animals with striatal lesions, particularly of the DLS, had blunted reward sensitivity and less stochasticity in the choice mechanism. These results provide further evidence that the rodent DLS is involved in rapid response adaptation that is more sophisticated than that embodied by the classic notion of habit formation driven by gradual stimulus-response learning.
引用
收藏
页码:1655 / 1663
页数:9
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