Rapid fluorous Stille coupling reactions conducted under microwave irradiation

被引：105

作者：

Larhed, M

Hoshino, M

Hadida, S

Curran, DP

Hallberg, A

机构：

[1] UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15260

[2] UNIV UPPSALA,CTR BIOMED,DEPT ORGAN PHARMACEUT CHEM,S-75123 UPPSALA,SWEDEN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 16期

关键词：

D O I：

10.1021/jo970362y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed fluorous Stille cross-coupling reactions with organic halides or triflates require only 90-120 s for completion when conducted under microwave irradiation. Comparable thermal reactions require about 1 day. Fourteen different coupling products were synthesized and isolated in good yields after three-phase extraction (FC-84, dichloromethane, water) and chromatography. The examples extend the scope of the fluorous Stille coupling with respect to both the tin and halide/triflate components. Applications in parallel synthesis are suggested.

引用

页码：5583 / 5587

页数：5

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