The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains

被引:138
作者
deMare, F
Kurtz, DM
Nordlund, P
机构
[1] UNIV STOCKHOLM,DEPT BIOL MOLEC,S-10691 STOCKHOLM,SWEDEN
[2] UNIV GEORGIA,DEPT CHEM,ATHENS,GA 30602
[3] UNIV GEORGIA,CTR METALLOENZYME STUDIES,ATHENS,GA 30602
来源
NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 06期
关键词
D O I
10.1038/nsb0696-539
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have determined the structure of rubrerythrin, a non-haem iron protein from the anaerobic sulphate-reducing bacterium, Desulfovibrio vulgaris (Hildenborough), by X-ray crystallography. The structure reveals a tetramer of two-domain subunits. Each subunit contains a four-helix bundle surrounding a diiron-oxo site and a C-terminal rubredoxin-like FeS4 domain. The diiron-oxo site contains a larger number of carboxylate ligands and a higher degree of solvent exposure than do those in other diiron-oxo proteins. The four-helix bundle of rubrerythrin closely resembles those of the ferritin and bacterioferritin subunits, suggesting a relationship among these proteins-consistent with the recently demonstrated ferroxidase activity of rubrerythrin.
引用
收藏
页码:539 / 546
页数:8
相关论文
共 45 条
  • [1] ADMAN E, 1975, P NATL ACAD SCI USA, V72, P4854, DOI 10.1073/pnas.72.12.4854
  • [2] BACTERIOFERRITINS AND FERRITINS ARE DISTANTLY RELATED IN EVOLUTION - CONSERVATION OF FERROXIDASE-CENTER RESIDUES
    ANDREWS, SC
    SMITH, JMA
    YEWDALL, SJ
    GUEST, JR
    HARRISON, PM
    [J]. FEBS LETTERS, 1991, 293 (1-2) : 164 - 168
  • [3] [Anonymous], ACTA CRYSTALLOGR D
  • [4] IRON (II) OXIDATION AND EARLY INTERMEDIATES OF IRON-CORE FORMATION IN RECOMBINANT HUMAN H-CHAIN FERRITIN
    BAUMINGER, ER
    HARRISON, PM
    HECHEL, D
    HODSON, NW
    NOWIK, I
    TREFFRY, A
    YEWDALL, SJ
    [J]. BIOCHEMICAL JOURNAL, 1993, 296 : 709 - 719
  • [5] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES
    BERNSTEIN, FC
    KOETZLE, TF
    WILLIAMS, GJB
    MEYER, EF
    BRICE, MD
    RODGERS, JR
    KENNARD, O
    SHIMANOUCHI, T
    TASUMI, M
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) : 535 - 542
  • [6] BONOMI F, 1996, J INORG BIOCHEM, V1, P69
  • [7] CRYSTALLOGRAPHIC R-FACTOR REFINEMENT BY MOLECULAR-DYNAMICS
    BRUNGER, AT
    KURIYAN, J
    KARPLUS, M
    [J]. SCIENCE, 1987, 235 (4787) : 458 - 460
  • [8] TYROSYL RADICAL FORMATION DURING THE OXIDATIVE DEPOSITION OF IRON IN HUMAN APOFERRITIN
    CHENBARRETT, Y
    HARRISON, PM
    TREFFRY, A
    QUAIL, MA
    AROSIO, P
    SANTAMBROGIO, P
    CHASTEEN, ND
    [J]. BIOCHEMISTRY, 1995, 34 (24) : 7847 - 7853
  • [9] RESONANCE RAMAN-SPECTROSCOPIC EVIDENCE FOR THE FES4 AND FE-O-FE SITES IN RUBRERYTHRIN FROM DESULFOVIBRIO-VULGARIS
    DAVE, BC
    CZERNUSZEWICZ, RS
    PRICKRIL, BC
    KURTZ, DM
    [J]. BIOCHEMISTRY, 1994, 33 (12) : 3572 - 3576
  • [10] X-RAY CRYSTAL-STRUCTURES OF THE OXIDIZED AND REDUCED FORMS OF THE RUBREDOXIN FROM THE MARINE HYPERTHERMOPHILIC ARCHAEBACTERIUM PYROCOCCUS-FURIOSUS
    DAY, MW
    HSU, BT
    JOSHUATOR, L
    PARK, JB
    ZHOU, ZH
    ADAMS, MWW
    REES, DC
    [J]. PROTEIN SCIENCE, 1992, 1 (11) : 1494 - 1507