SPONTANEOUS NEURONAL ACTIVITY PREDICTS INTERSUBJECT VARIATIONS IN EXECUTIVE CONTROL OF ATTENTION

被引：46
作者：
Xu, J. [1 ,2 ,3 ]
Rees, G. [2 ,3 ]
Yin, X. [1 ]
Song, C. [2 ]
Han, Y. [4 ]
Ge, H. [1 ]
Pang, Z. [5 ]
Xu, W. [4 ]
Tang, Y. [1 ]
Friston, K.J. [3 ]
Liu, S. [1 ]
机构：
[1] Shandong Univ, Sch Med, Res Ctr Sect & Imaging Anat, Jinan 250012, Shandong, Peoples R China
[2] UCL Inst Cognit Neurosci, London, England
[3] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, London, England
[4] Qingdao Univ, Dept Radiol, Affiliated Hosp, Coll Med, Qingdao 266071, Shandong, Peoples R China
[5] Qingdao Municipal Cent Dis Control & Prevent, Dept Epidemiol, Qingdao, Shandong, Peoples R China
来源：
NEUROSCIENCE | 2014年 / 263卷
基金：
中国国家自然科学基金; 中国博士后科学基金; 英国惠康基金;
关键词：
resting-state fMRI; ALFF; functional connectivity; executive control; LINE BRAIN ACTIVITY; FUNCTIONAL CONNECTIVITY; NETWORKS; CORTEX; FMRI; TASK; PERFORMANCE; INDEPENDENCE; VARIABILITY; ACTIVATION;
D O I：
10.1016/j.neuroscience.2014.01.020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Executive control of attention regulates our thoughts, emotion and behavior. Individual differences in executive control are associated with task-related differences in brain activity. But it is unknown whether attentional differences depend on endogenous (resting state) brain activity and to what extent regional fluctuations and functional connectivity contribute to individual variations in executive control processing. Here, we explored the potential contribution of intrinsic brain activity to executive control by using resting-state functional magnetic resonance imaging (fMRI). Using the amplitude of low-frequency fluctuations (ALFF) as an index of spontaneous brain activity, we found that ALFF in the right precuneus (PCUN) and the medial part of left superior frontal gyrus (msFC) was significantly correlated with the efficiency of executive control processing. Crucially, the strengths of functional connectivity between the right PCUN/left msFC and distributed brain regions, including the left fusiform gyrus, right inferior frontal gyrus, left superior frontal gyrus and right precentral gyrus, were correlated with individual differences in executive performance. Together, the ALFF and functional connectivity accounted for 67% of the variability in behavioral performance. Moreover, the strength of functional connectivity between specific regions could predict more individual variability in executive control performance than regionally specific fluctuations. In conclusion, our findings suggest that spontaneous brain activity may reflect or underpin executive control of attention. It will provide new insights into the origins of inter-individual variability in human executive control processing. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：181 / 192
页数：12
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