Serum substance P and vasoactive intestinal peptide levels in infants with acute intussusception

被引：2

作者：

Zhu, Zhen-chuang ^{[1
]}

Wang, Hai-bin ^{[1
]}

Yan, Xue-qiang ^{[1
]}

Yang, Jun ^{[1
]}

Duan, Xu-fei ^{[1
]}

Bian, Hong-qiang ^{[1
]}

Kuang, Hou-fang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Childrens Hosp, 100 Hongkong Rd, Wuhan 430016, Hubei, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2019年 / 47卷 / 06期

关键词：

Intussusception; enteric nervous system; substance P; vasoactive intestinal peptide; inguinal hernia; infant; bowel; POLYPEPTIDE; DISEASE; VIP;

D O I：

10.1177/0300060519844401

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective We aimed to investigate the role of the intestinal neurotransmitters vasoactive intestinal peptide (VIP) and substance P (SP) at different time points in infants with acute intussusception. Methods Thirty patients who were diagnosed with acute intussusception were enrolled in the study and classified as the experimental group. Another 30 patients with an indirect inguinal hernia who had no intestinal injury were included as the control group. Serum SP and VIP levels at different time points, including pre- and postoperation, were detected by enzyme-linked immunosorbent assay and compared between the two groups. Results Serum SP levels in patients with acute intussusception were significantly higher than those in controls. However, with recovery of acute intussusception, SP levels gradually decreased after treatment. Serum VIP levels in patients with acute intussusception were significantly lower than those in controls. However, with recovery of acute intussusception, VIP levels gradually increased after treatment. Conclusions SP and VIP levels may have a potential relationship with the pathogenetic process of intussusception.

引用

页码：2446 / 2451

页数：6

共 15 条

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