共 37 条
Safety and immunologic effects of high-vs low-dose cholecalciferol in multiple sclerosis
被引:108
作者:

Sotirchos, Elias S.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Bhargava, Pavan
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

论文数: 引用数:
h-index:
机构:

Van Haren, Keith
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Neurol, Palo Alto, CA 94304 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Baynes, Moira
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Ntranos, Achilles
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Gocke, Anne
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Steinman, Lawrence
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Neurol, Palo Alto, CA 94304 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Mowry, Ellen M.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Calabresi, Peter A.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
机构:
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2] Duke Univ, Sch Med, Dept Neurol, Durham, NC USA
[3] Stanford Univ, Sch Med, Dept Neurol, Palo Alto, CA 94304 USA
来源:
关键词:
VITAMIN-D SUPPLEMENTATION;
T-CELLS;
AUTOIMMUNE ENCEPHALOMYELITIS;
CONTROLLED-TRIAL;
25-HYDROXYVITAMIN D;
MONONUCLEAR-CELLS;
RELAPSE RISK;
DOUBLE-BLIND;
EXPRESSION;
MULTICENTER;
D O I:
10.1212/WNL.0000000000002316
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Objective:To study the safety profile and characterize the immunologic effects of high- vs low-dose cholecalciferol supplementation in patients with multiple sclerosis (MS).Methods:In this double-blind, single-center randomized pilot study, 40 patients with relapsing-remitting MS were randomized to receive 10,400 IU or 800 IU cholecalciferol daily for 6 months. Assessments were performed at baseline and 3 and 6 months.Results:Mean increase of 25-hydroxyvitamin D levels from baseline to final visit was larger in the high-dose group (34.9 ng/mL; 95% confidence interval [CI] 25.0-44.7 ng/mL) than in the low-dose group (6.9 ng/mL; 95% CI 1.0-13.7 ng/mL). Adverse events were minor and did not differ between the 2 groups. Two relapses occurred, one in each treatment arm. In the high-dose group, we found a reduction in the proportion of interleukin-17(+)CD4(+) T cells (p = 0.016), CD161(+)CD4(+) T cells (p = 0.03), and effector memory CD4(+) T cells (p = 0.021) with a concomitant increase in the proportion of central memory CD4(+) T cells (p = 0.018) and naive CD4(+) T cells (p = 0.04). These effects were not observed in the low-dose group.Conclusions:Cholecalciferol supplementation with 10,400 IU daily is safe and tolerable in patients with MS and exhibits in vivo pleiotropic immunomodulatory effects in MS, which include reduction of interleukin-17 production by CD4(+) T cells and decreased proportion of effector memory CD4(+) T cells with concomitant increase in central memory CD4(+) T cells and naive CD4(+) T cells.Classification of evidence:This study provides Class I evidence that cholecalciferol supplementation with 10,400 IU daily is safe and well-tolerated in patients with MS and exhibits in vivo pleiotropic immunomodulatory effects.
引用
收藏
页码:382 / 390
页数:9
相关论文
共 37 条
[1]
Coordinated expression of ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells
[J].
Anfossi, N
;
Doisne, JM
;
Peyrat, MA
;
Ugolini, S
;
Bonnaud, O
;
Bossy, D
;
Pitard, V
;
Merville, P
;
Moreau, JF
;
Delfraissy, JF
;
Dechanet-Merville, J
;
Bonneville, M
;
Venet, A
;
Vivier, E
.
JOURNAL OF IMMUNOLOGY,
2004, 173 (12)
:7223-7229

Anfossi, N
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Doisne, JM
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Peyrat, MA
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Ugolini, S
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Bonnaud, O
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Bossy, D
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Moreau, JF
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Delfraissy, JF
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Dechanet-Merville, J
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Bonneville, M
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Venet, A
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France

Vivier, E
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France
[2]
1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls
[J].
Bhargava, Pavan
;
Gocke, Anne
;
Calabresi, Peter A.
.
JOURNAL OF NEUROIMMUNOLOGY,
2015, 279
:20-24

Bhargava, Pavan
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Gocke, Anne
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Calabresi, Peter A.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[3]
The Vitamin D to Ameliorate Multiple Sclerosis (VIDAMS) trial: Study design for a multicenter, randomized, double-blind controlled trial of vitamin D in multiple sclerosis
[J].
Bhargava, Pavan
;
Cassard, Sandra
;
Steele, Sonya U.
;
Azevedo, Christina
;
Pelletier, Daniel
;
Sugar, Elizabeth A.
;
Waubant, Emmanuelle
;
Mowry, Ellen M.
.
CONTEMPORARY CLINICAL TRIALS,
2014, 39 (02)
:288-293

Bhargava, Pavan
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

Cassard, Sandra
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

Steele, Sonya U.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

Azevedo, Christina
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Neurol, Yale Multiple Sclerosis Ctr, New Haven, CT 06520 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

Pelletier, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Neurol, Yale Multiple Sclerosis Ctr, New Haven, CT 06520 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

Sugar, Elizabeth A.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Publ Hlth, Dept Biostat, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

Waubant, Emmanuelle
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

Mowry, Ellen M.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA
[4]
Chemokine receptor expression on MBP-reactive T cells:: CXCR6 is a marker of IFN-γ-producing effector cells
[J].
Calabresi, PA
;
Yun, SH
;
Allie, R
;
Whartenby, KA
.
JOURNAL OF NEUROIMMUNOLOGY,
2002, 127 (1-2)
:96-105

Calabresi, PA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

Yun, SH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

Allie, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

Whartenby, KA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
[5]
1,25-dihydroxyvitamin D-3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
[J].
Cantorna, MT
;
Hayes, CE
;
DeLuca, HF
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1996, 93 (15)
:7861-7864

Cantorna, MT
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706 UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

Hayes, CE
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706 UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

DeLuca, HF
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706 UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706
[6]
A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
[J].
Colonna, M
;
Navarro, F
;
Bellon, T
;
Llano, M
;
Garcia, P
;
Samaridis, J
;
Angman, L
;
Cella, M
;
LopezBotet, M
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1997, 186 (11)
:1809-1818

Colonna, M
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

Navarro, F
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

Bellon, T
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

Llano, M
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

Garcia, P
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

Samaridis, J
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

Angman, L
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

Cella, M
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN

LopezBotet, M
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV PRINCESA, MADRID 28006, SPAIN HOSP UNIV PRINCESA, MADRID 28006, SPAIN
[7]
Gender Differences in 1,25 Dihydroxyvitamin D3 Immunomodulatory Effects in Multiple Sclerosis Patients and Healthy Subjects
[J].
Correale, Jorge
;
Ysrraelit, Maria C.
;
Gaitan, Maria I.
.
JOURNAL OF IMMUNOLOGY,
2010, 185 (08)
:4948-4958

Correale, Jorge
论文数: 0 引用数: 0
h-index: 0
机构:
Raul Carrea Inst Neurol Res, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina Raul Carrea Inst Neurol Res, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina

Ysrraelit, Maria C.
论文数: 0 引用数: 0
h-index: 0
机构:
Raul Carrea Inst Neurol Res, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina Raul Carrea Inst Neurol Res, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina

Gaitan, Maria I.
论文数: 0 引用数: 0
h-index: 0
机构:
Raul Carrea Inst Neurol Res, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina Raul Carrea Inst Neurol Res, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina
[8]
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
[J].
Cosmi, Lorenzo
;
De Palma, Raffaele
;
Santarlasci, Veronica
;
Maggi, Laura
;
Capone, Manuela
;
Frosali, Francesca
;
Rodolico, Gabriella
;
Querci, Valentina
;
Abbate, Gianfranco
;
Angeli, Roberta
;
Berrino, Liberato
;
Fambrini, Massimiliano
;
Caproni, Marzia
;
Tonelli, Francesco
;
Lazzeri, Elena
;
Parronchi, Paola
;
Liotta, Francesco
;
Maggi, Enrico
;
Romagnani, Sergio
;
Annunziato, Francesco
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2008, 205 (08)
:1903-1916

论文数: 引用数:
h-index:
机构:

De Palma, Raffaele
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Naples 2, Dept Clin & Expt Med, I-80131 Naples, Italy
Ctr Reg Competenza Genom, I-80131 Naples, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Santarlasci, Veronica
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Maggi, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Capone, Manuela
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Frosali, Francesca
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Rodolico, Gabriella
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Naples 2, Sect Pharmacol Sci, I-80131 Naples, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Querci, Valentina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Abbate, Gianfranco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Naples 2, Dept Clin & Expt Med, I-80131 Naples, Italy
Ctr Reg Competenza Genom, I-80131 Naples, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Angeli, Roberta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Berrino, Liberato
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Naples 2, Sect Pharmacol Sci, I-80131 Naples, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Fambrini, Massimiliano
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Gynecol Perinatol & Human Reprod, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

论文数: 引用数:
h-index:
机构:

Tonelli, Francesco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Pathophysiol, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Lazzeri, Elena
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Parronchi, Paola
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Liotta, Francesco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

论文数: 引用数:
h-index:
机构:

Romagnani, Sergio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy

Annunziato, Francesco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy Univ Florence, Dept Internal Med, I-50134 Florence, Italy
[9]
Efficacy of Vitamin D Supplementation in Multiple Sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial
[J].
Doerr, Jan
;
Ohlraun, Stephanie
;
Skarabis, Horst
;
Paul, Friedemann
.
TRIALS,
2012, 13

Doerr, Jan
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany
Charite, Clin & Expt Multiple Sclerosis Ctr, D-13353 Berlin, Germany Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany

Ohlraun, Stephanie
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany

Skarabis, Horst
论文数: 0 引用数: 0
h-index: 0
机构: Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany

Paul, Friedemann
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany
Charite, Clin & Expt Multiple Sclerosis Ctr, D-13353 Berlin, Germany
Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany
[10]
1,25-Dihydroxyvitamin D3 selectively and reversibly impairs T helper-cell CNS localization
[J].
Grishkan, Inna V.
;
Fairchild, Amanda N.
;
Calabresi, Peter A.
;
Gocke, Anne R.
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2013, 110 (52)
:21101-21106

Grishkan, Inna V.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

Fairchild, Amanda N.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

Calabresi, Peter A.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

Gocke, Anne R.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA