The Effect of Unsaturation on the Formation of Self-Assembled Gels from Fatty Acid L-Serine Amides and their Cytotoxicity Towards Caco-2 Cancer Cells

被引：8
作者：
Lim, Li Yun Grace [1 ]
Su, Yingying [2 ]
Braet, Filip [2 ]
Thordarson, Pall [1 ]
机构：
[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia
[2] Univ Sydney, Australian Key Ctr Microscopy & Microanal, Sydney, NSW 2006, Australia
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2009年 / 62卷 / 07期
基金：
澳大利亚研究理事会;
关键词：
DELIVERY; GROWTH;
D O I：
10.1071/CH09211
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of saturated and unsaturated fatty acid L-serines 3 were synthesized and their ability to form self-assembled gels was investigated. The saturated (lauroyl 3a and steraoyl 3b) and monounsaturated (oleoyl 3c) fatty acid L-serines form gels in both water and organic solvent, whereas the diunsaturated linoleyl-L-serine 3d does not form gels in these solvents, indicating that unsaturation adversely affects the gelation process. Cytotoxicity studies on these compounds with Caco-2 cancer cells in vitro show that these gels are only moderately cytotoxic at concentrations up to 0.5 mM, making them a promising candidate for applications such as drug delivery.
引用
收藏
页码：653 / 656
页数：4
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