Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications

被引：24

作者：

Gong, Yanbao ^{[1
]}

Fan, Mingxia ^{[2
]}

Gao, Feng ^{[1
]}

Hong, Jun ^{[1
]}

Liu, Shunying ^{[1
]}

Luo, Shufang ^{[1
]}

Yu, Jiahui ^{[1
]}

Huang, Jin ^{[3
]}

机构：

[1] E China Normal Univ, Coll New Drug Innovat Res & Dev, Shanghai 200062, Peoples R China

[2] E China Normal Univ, Shanghai Key Lab FMRI, Shanghai 200062, Peoples R China

[3] Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2009年 / 71卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Photopolymerization; Core-shell magnetic nanogels; Amino-functionalized; Superparamagnetism; Magnetic resonance imaging (MRI); RADICAL POLYMERIZATION; METHYL-METHACRYLATE; LATEX-PARTICLES; NANOPARTICLES;

D O I：

10.1016/j.colsurfb.2009.02.012

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM center dot HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infra red spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%). high saturation magnetizations and superparamagnetic behavior Suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r(2) and coronal image of the crossing of mouse kidney. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：243 / 247

页数：5

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