Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications

To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM center dot HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infra red spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%). high saturation magnetizations and superparamagnetic behavior Suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r(2) and coronal image of the crossing of mouse kidney. (C) 2009 Elsevier B.V. All rights reserved.