Radiogenomic evaluation of lung cancer Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?

被引：11

作者：

Halpenny, Darragh F. ^{[1
]}

Plodkowski, Andrew ^{[1
]}

Riely, Gregory ^{[2
]}

Zheng, Junting ^{[3
]}

Litvak, Anya ^{[2
]}

Moscowitz, Chaya ^{[3
]}

Ginsberg, Michelle S. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, Div Solid Tumor Oncol, Dept Thorac Oncol Serv, 1275 York Ave, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, 1275 York Ave, New York, NY 10065 USA

来源：

CLINICAL IMAGING | 2017年 / 42卷

关键词：

Lung carcinoma; BRAE mutation; Computed tomography; Radiogenomics; GROWTH-FACTOR RECEPTOR; PULMONARY ADENOCARCINOMA; CT CHARACTERISTICS; FEATURES; GENE; VEMURAFENIB; CARCINOMA; EGFR;

D O I：

10.1016/j.clinimag.2016.11.015

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Introduction: We studied computed tomography (CT) features associated with BRAF mutated lung cancer. Materials and methods: cT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation. Results: 47 (25%) patients with BRAF mutation and 141 (75%) without BRAF mutation were included. BRAF lesions were most frequently solid 37(84%), spiculated 22(50%), and peripheral 37(84%). No feature of the primary tumor was significantly different between BRAF and non-BRAF groups. BRAF patients were more likely than KRAS patients to have pleural metastases [5 (11%) vs 0 (0%), p = 0.0451. Conclusion: No feature of the primary tumor differentiates BRAF lesions from non-BRAF lesions. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：147 / 151

页数：5

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