SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS

被引：0

作者：

Hayallah, Alaa M. ^{[1
]}

Heta, Helal F. ^{[2
]}

机构：

[1] Assiut Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Assiut 71526, Egypt

[2] Assiut Univ, Fac Med, Dept Microbiol & Immunol, Assiut 71526, Egypt

来源：

BULLETIN OF PHARMACEUTICAL SCIENCES | 2008年 / 31卷

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present work some new 1,3,5-trisubstituted[1,2,4]triazole derivatives and their Schiffs bases were synthesized The chemical structure of the target compounds was confirmed by IR, H-1-NMR, C-13-NMR, FAB-MS, EI-HRMS spectra and elemental analyses. The title compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative ones using ampicillin and nalidixic acid as reference drugs. Some of them showed antibacterial activity more significant than the reference drugs.

引用

页码：375 / 390

页数：16

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