Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease

被引：15
|
作者：
Brickman, Adam M. [1 ,2 ,3 ]
Manly, Jennifer J. [1 ,2 ,3 ]
Honig, Lawrence S. [1 ,2 ,3 ]
Sanchez, Danurys [1 ,2 ,3 ]
Reyes-Dumeyer, Dolly [1 ,2 ,3 ]
Lantigua, Rafael A. [1 ,4 ]
Vonsattel, Jean Paul [1 ,4 ,5 ]
Teich, Andrew F. [1 ,5 ]
Kang, Min Suk [1 ]
Dage, Jeffrey L. [6 ,7 ]
Mayeux, Richard [1 ,2 ,3 ]
机构：
[1] Columbia Univ, Vagelos Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA
[2] Columbia Univ, Vagelos Coll Phys & Surg, GH Sergievsky Ctr, New York, NY 10027 USA
[3] Columbia Univ, Vagelos Coll Phys & Surg, Dept Neurol, New York, NY USA
[4] New York Presbyterian Hosp, New York, NY USA
[5] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, New York, NY USA
[6] Columbia Univ, Vagelos Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY USA
[7] Indiana Univ, Sch Med, Stark Neurosci Res Inst, Indianapolis, IN USA
来源：
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2022年 / 9卷 / 05期
基金：
美国国家卫生研究院;
关键词：
DEMENTIA; TAU;
D O I：
10.1002/acn3.51529
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Blood-based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau-) based on Ptau 181 and 217 concentrations and as cognitively impaired (Sym) or unimpaired (Asym). The four groups, Ptau-/Asym, Ptau+/Asym, Ptau-/Sym, and Ptau+/Sym, differed by age, APOE-4 allele frequency, total tau, neurofilament light chain, and cortical thickness measured by MRI. Our results add to increasing evidence that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations.
引用
收藏
页码：756 / 761
页数：6
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