Urinary proteins detected using modern proteomics intervene in early type 2 diabetic kidney disease - a pilot study

被引：9

作者：

Golea-Secara, Alina ^{[1
,2
]}

Munteanu, Cristian ^{[3
]}

Sarbu, Mirela ^{[4
]}

Cretu, Octavian M. ^{[2
,5
]}

Velciov, Silvia ^{[1
,2
]}

Vlad, Adrian ^{[2
,6
]}

Bob, Flaviu ^{[1
,2
]}

Gadalean, Florica ^{[1
,2
]}

Gluhovschi, Cristina ^{[2
]}

Milas, Oana ^{[1
,2
]}

Simulescu, Anca ^{[1
,2
]}

Mogos-Stefan, Maria ^{[1
,2
]}

Patruica, Mihaela ^{[1
,2
]}

Petrica, Ligia ^{[1
,2
,7
]}

Zamfir, Alina D. ^{[4
]}

机构：

[1] Cty Emergency Hosp Timisoara, Dept Nephrol, Timisoara, Romania

[2] Victor Babes Univ Med & Pharm, Timisoara, Romania

[3] Inst Biochem, Dept Bioinformat & Struct Biochem, Bucharest, Romania

[4] Natl Inst Res & Dev Electrochem & Condensed Matte, Timisoara, Romania

[5] Municipal Emergency Hosp Timisoara, Dept Surg 1, Timisoara, Romania

[6] Cty Emergency Hosp, Dept Diabet & Metab Dis, Timisoara, Romania

[7] Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara, Romania

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 16期

关键词：

albuminuria; diabetes mellitus Type 2; inflammation; proximal tubule dysfunction; urinary proteomics; BIOMARKERS; IDENTIFICATION; NEPHROPATHY; PATHOPHYSIOLOGY; EXPRESSION; PEPTIDES;

D O I：

10.2217/bmm-2020-0308

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim:An advanced proteomics platform for protein biomarker discovery in diabetic chronic kidney disease (DKD) was developed, validated and implemented.Materials & methods:Three Type 2 diabetes mellitus patients and three control subjects were enrolled. Urinary peptides were extracted, samples were analyzed on a hybrid LTQ-Orbitrap Velos Pro instrument. Raw data were searched using the SEQUEST algorithm and integrated into Proteome Discoverer platform.Results & discussion:Unique peptide sequences, resulted sequence coverage, scoring of peptide spectrum matches were reported to albuminuria and databases. Five proteins that can be associated with early DKD were found: apolipoprotein AI, neutrophil gelatinase-associated lipocalin, cytidine deaminase, S100-A8 and hemoglobin subunit delta.Conclusion:Urinary proteome analysis could be used to evaluate mechanisms of pathogenesis of DKD.

引用

页码：1521 / 1537

页数：17

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