In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates

被引：12

作者：

Sleha, Radek ^{[1
,2
]}

Mosio, Petra ^{[1
]}

Vydrzalova, Marketa ^{[1
]}

Jantovska, Alexandra ^{[1
]}

Bostikova, Vanda ^{[2
]}

Mazurova, Jaroslava ^{[1
]}

机构：

[1] Univ Pardubice, Fac Chem Technol, Dept Biol & Biochem, Pardubice, Czech Republic

[2] Univ Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic

来源：

BIOMEDICAL PAPERS-OLOMOUC | 2014年 / 158卷 / 02期

关键词：

Mycoplasma hominis; antimicrobial agents; minimal inhibitory concentration; natural substances; ANTIMYCOPLASMAL ACTIVITY; RESISTANCE; SUSCEPTIBILITIES; FLUOROQUINOLONES; ANTIBACTERIAL; INFECTION;

D O I：

10.5507/bp.2012.083

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Aims. The aim of this study was to evaluate the antimicrobial effects of five natural substances against 50 clinical isolates of Mycoplasma hominis. Methods and Results. The in vitro activity of selected natural compounds, cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene, was investigated against 50 M. hominis isolates cultivated from cervical swabs by the broth dilution method. All showed valuable antimicrobial activity against the tested isolates. Oil from the bark of Cinnamomum zeylanicum (MBC90 = 500 g/mL) however was found to be the most effective. Carvacrol (MBC90 = 600 g/mL) and eugenol (MBC90 = 1000 g/mL) also possessed strong antimycoplasmal activity. Conclusions. The results indicate that cinnamon bark oil, carvacrol and eugenol have strong antimycoplasmal activity and the potential for use as antimicrobial agents in the treatment of mycoplasmal infections.

引用

页码：208 / 211

页数：4

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