Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

被引：92
作者：
Bowen, Joanne M. [1 ]
Gibson, Rachel J.
Cummins, Adrian G.
Keefe, Dorothy M. K.
机构：
[1] Univ Adelaide, Dept Med, Adelaide, SA 5001, Australia
[2] Royal Adelaide Hosp, Dept Med Oncol, Adelaide, SA 5000, Australia
[3] Queen Elizabeth Hosp, Dept Gastroenterol & Hepatol, Adelaide, SA, Australia
来源：
SUPPORTIVE CARE IN CANCER | 2006年 / 14卷 / 07期
关键词：
mucositis; p53; Bcl-2; family; caspases;
D O I：
10.1007/s00520-005-0004-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.
引用
收藏
页码：713 / 731
页数：19
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