Management of hepatocellular carcinoma recurrence after liver transplantation

被引:19
作者
Agarwal, Parul D. [1 ]
Lucey, Michael R. [1 ]
机构
[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Gastroenterol & Hepatol, 1685 Highland Ave,Suite 4224, Madison, WI 53705 USA
关键词
(In addition to title); Alpha fetoprotein; Ablation; Trans-arterial chemoembolization; Chemotherapy; SORAFENIB; RECIPIENTS; THERAPY; PHASE-3;
D O I
10.1016/j.aohep.2021.100654
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Despite careful selection for liver transplantation (LT) of patients with hepatocellular carcinoma (HCC), HCC may still recur after LT and is frequently associated with dismal outcome. Tumor factors, including serum alpha-fetoprotein (AFP), the presence of microvascular invasion, tumor grade/differentiation, and largest tumor size are amongst the most important predictors of recurrence after transplantation. The nature of recurrence can be highly variable, but often presents with extra-hepatic involvement. As such, management of patients with HCC can be challenging, and consensus guidelines are lacking. Curative options, with surgery or ablation, which may be applicable in patients with isolated intra-or extrahepatic metastases, offer the best chance for improved long-term outcome in patients with HCC recurrence after transplantation. Most patients with recurrence have unresectable disease, and may benefit from palliative treatments, including intra-arterial therapies and/or systemic therapy. (c) 2021 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
引用
收藏
页数:3
相关论文
共 50 条
[41]   The Value of Serum α-Fetoprotein in Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma [J].
Xu, Xiao ;
Ke, Qing-Hong ;
Shao, Zhe-Xin ;
Wu, Jian ;
Chen, Jun ;
Zhou, Lin ;
Zheng, Shu-Sen .
DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (02) :385-388
[42]   Long-term observation of hepatocellular carcinoma recurrence after liver transplantation at a European transplantation centre [J].
Foerster, Friedrich ;
Hoppe-Lotichius, Maria ;
Vollmar, Johanna ;
Marquardt, Jens U. ;
Weinmann, Arndt ;
Woerns, Marcus-Alexander ;
Otto, Gerd ;
Zimmermann, Tim ;
Galle, Peter R. .
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 2019, 7 (06) :838-849
[43]   Liver transplantation for hepatocellular carcinoma: outcomes and treatment options for recurrence [J].
Rahimi, Robert S. ;
Trotter, James F. .
ANNALS OF GASTROENTEROLOGY, 2015, 28 (03) :323-330
[44]   Liver transplantation for hepatocellular carcinoma: is zero recurrence theoretically possible? [J].
Irtan, Sabine ;
Barbier, Louise ;
Francoz, Claire ;
Dondero, Federica ;
Durand, Francois ;
Belghiti, Jacques .
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2016, 15 (02) :147-151
[45]   Liver Transplantation for Hepatocellular Carcinoma: Five Steps to Prevent Recurrence [J].
Toso, C. ;
Mentha, G. ;
Majno, P. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 (10) :2031-2035
[46]   Validity of eleven prognostic scores with respect to intra- and extrahepatic recurrence of hepatocellular carcinoma after liver transplantation [J].
Bauschke, A. ;
Altendorf-Hofmann, A. ;
Kissler, H. ;
Koch, A. ;
Malessa, C. ;
Settmacher, U. .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2017, 143 (12) :2595-2605
[47]   A Simple Measure of Hepatocellular Carcinoma Burden Predicts Tumor Recurrence After Liver Transplantation: The Recurrent Hepatocellular Carcinoma-Initial Maximum , Last Classification [J].
Vutien, Philip ;
Dodge, Jennifer ;
Bambha, Kiran M. ;
Nordstrom, Eric M. ;
Gralla, Jane ;
Campbell, Kristen ;
Levek, Claire ;
Nydam, Trevor ;
Fix, Oren ;
Ioannou, George ;
Biggins, Scott W. .
LIVER TRANSPLANTATION, 2019, 25 (04) :559-570
[48]   Recurrence of Hepatocellular Carcinoma in Noncirrhotic Liver After Hepatectomy [J].
Laurence Chiche ;
B. Menahem ;
C. Bazille ;
V. Bouvier ;
L. Plard ;
V. Saguet ;
A. Alves ;
E. Salame .
World Journal of Surgery, 2013, 37 :2410-2418
[49]   Recurrence of Hepatocellular Carcinoma after Living Donor Liver Transplantation: What is the Current Optimal Approach to Prevent Recurrence? [J].
Toshimi Kaido ;
Akira Mori ;
Yasuhiro Ogura ;
Koichiro Hata ;
Atsushi Yoshizawa ;
Taku Iida ;
Shinji Uemoto .
World Journal of Surgery, 2011, 35 :1355-1359
[50]   Hepatocellular carcinoma recurrence: Predictors and management [J].
Abdelhamed, Walaa ;
El-Kassas, Mohamed .
LIVER RESEARCH, 2023, 7 (04) :321-332