Genetics of Spontaneous Intracerebral Hemorrhage: Risk and Outcome

被引:10
作者
Guo, Hongxiu [1 ]
You, Mingfeng [1 ]
Wu, Jiehong [1 ]
Chen, Anqi [1 ]
Wan, Yan [1 ]
Gu, Xinmei [1 ]
Tan, Senwei [1 ]
Xu, Yating [1 ]
He, Quanwei [1 ]
Hu, Bo [1 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurol, Wuhan, Peoples R China
基金
中国国家自然科学基金;
关键词
intracerebral hemorrhage; genetic variation; human genetics; incidence; prognosis; APOLIPOPROTEIN-E GENOTYPE; THR312ALA POLYMORPHISM; CEREBRAL-HEMORRHAGE; HEMATOMA EXPANSION; C677T POLYMORPHISM; INCREASES RISK; BIRTH-WEIGHT; STROKE; ASSOCIATION; RS4646994;
D O I
10.3389/fnins.2022.874962
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Spontaneous intracerebral hemorrhage (ICH) is a common fatal event without an effective therapy. Of note, some familial aggregation and inherited tendency is found in ICH and heritability estimates indicate that genetic variations contribute substantially to ICH risk and outcome. Thus, identification of genetic variants that affect the occurrence and outcome may be helpful for ICH prevention and therapy. There are several reviews summarizing numerous genetic variants associated with the occurrence of ICH before, but genetic variants contributing to location distribution and outcome have rarely been introduced. Here, we summarize the current knowledge of genetic variants and pay special attention to location distribution and outcome. So far, investigations have reveled variations in APOE, GPX1, CR1, ITGAV, PRKCH, and 12q21.1 are associated with lobar ICH (LICH), while ACE, COL4A2, 1q22, TIMP1, TIMP2, MMP2, MMP9, and TNF are associated with deep ICH (DICH). Moreover, variations in APOE, VWF, 17p12, HP, CFH, IL6ST, and COL4A1 are possible genetic contributors to ICH outcome. Furthermore, the prospects for ICH related genetic studies from the bench to the bed were discussed.
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页数:14
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