A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma

被引：45

作者：

Zhou, Bin ^{[1
]}

Rao, Li ^{[2
]}

Li, Yi ^{[3
]}

Gao, Linbo ^{[4
]}

Wang, Yanyun ^{[3
]}

Chen, Yu ^{[2
]}

Xue, Hui ^{[2
]}

Song, Yaping ^{[1
]}

Peng, Ying ^{[2
]}

Liao, Miao ^{[4
]}

Zhang, Lin ^{[1
]}

机构：

[1] Sichuan Univ, Lab Mol Translat Med, W China Univ Hosp 2, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Dept Cardiol, W China Hosp, Chengdu 610041, Peoples R China

[3] Sichuan Univ, Dept Immunol, W China Sch Preclin & Forens Med, Chengdu 610041, Peoples R China

[4] Sichuan Univ, Dept Forens Biol, W China Sch Preclin & Forens Med, Chengdu 610041, Peoples R China

来源：

CANCER LETTERS | 2009年 / 275卷 / 01期

关键词：

Nasopharyngeal carcinoma; NF-kappa B; NFKB1; Genetic association; Polymorphism; MEMBRANE-PROTEIN; 1; FACTOR-KAPPA-B; BARR-VIRUS INFECTION; RISK; EXPRESSION; GROWTH; INHIBITOR; ALPHA; HEAD;

D O I：

10.1016/j.canlet.2008.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nasopharyngeal carcinoma (NPC) is a common malignancy in southern China and Southeast Asia. Nuclear factor-kappa (NF-kappa B)-activation plays critical roles in Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) mediated tumorigenesis in NPC. A functional insertion/deletion polymorphism (-94 insertion/deletion ATTG) in the promoter of NFKB1 gene, which encodes the p50 subunit of NF-kappa B protein complex, was recently identified. This study found that the frequency of ATTG(2) allele in NPC patients was significantly higher than that in control subjects (66% vs. 57.1 %, p = 0.015, OR = 1.453), suggesting that the functional NFKB1 promoter polymorphism is associated with increased risk for NPC. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：72 / 76

页数：5

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