Recent progress in nanoformulations of cabazitaxel

被引：16
作者：
Chen, Yu [1 ,2 ]
Pan, Yue [1 ,2 ]
Hu, Danrong [1 ,2 ]
Peng, Jinrong [1 ,2 ]
Hao, Ying [1 ,2 ]
Pan, Meng [1 ,2 ]
Yuan, Liping [1 ,2 ]
Yu, Yongyang [3 ]
Qian, Zhiyong [1 ,2 ]
机构：
[1] Sichuan Univ, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, West China Hosp,West China Med Sch, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Ctr Canc, Collaborat Innovat Ctr Biotherapy, West China Hosp,West China Med Sch, Chengdu 610041, Peoples R China
[3] Sichuan Univ, Dept Gastrointestinal Surg, West China Hosp, Chengdu 610041, Peoples R China
来源：
BIOMEDICAL MATERIALS | 2021年 / 16卷 / 03期
基金：
中国国家自然科学基金;
关键词：
taxane resistance; cabazitaxel; P-gp; Jevtana® nanomedicine;
D O I：
10.1088/1748-605X/abe396
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The antitumor efficacy of various paclitaxel (PTX) and docetaxel (DTX) formulations in clinical applications is seriously affected by drug resistance. Cabazitaxel, a second-generation taxane, exhibits greater anticancer activity than PTX and DTX and has low affinity for the P-glycoprotein efflux pump because of its structure. Therefore, cabazitaxel has the potential to overcome taxane resistance. However, owing to the high systemic toxicity and hydrophobicity of cabazitaxel and the instability of its commercial preparation, Jevtana (R), the clinical use of cabazitaxel is restricted to patients with metastatic castration-resistant prostate cancer who show progression after DTX-based chemotherapy. Nanomedicine is expected to overcome the limitations associated with cabazitaxel application and surmount taxane resistance. This review outlines the drug delivery systems of cabazitaxel published in recent years, summarizes the challenges faced in the development of cabazitaxel nanoformulations, and proposes strategies to overcome these challenges.
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页数：12
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