Effects of ApoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes

被引：29

作者：

Guo, Shuzhen

Wang, Sophia

Kim, Woo Jean

Lee, Sun-Ryung

Frosch, Matthew P.

Bacskai, Brian J.

Greenberg, Steven M.

Lo, Eng H. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA

[2] Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA USA

[3] Massachusetts Gen Hosp, Alzheimers Dis Res Unit, Charlestown, MA USA

[4] Mt Sinai Sch Med, New York, NY USA

[5] Jeju Natl Univ, Cheju, South Korea

来源：

BRAIN RESEARCH | 2006年 / 1111卷

关键词：

Alzheimer's disease; proteolysis; ApoE;

D O I：

10.1016/j.brainres.2006.06.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Matrix metalloproteinase-9 (MMP-9) may play a role in the inflammatory glial response during Alzheimer's disease (AD). Astrocytes can degrade beta-amyloid (A beta) and extracellular proteolysis via MMP-9 may be involved. Because Apolipoprotein E (APOE) genotype is an important factor for AD, we ask whether various apoE isoforms can influence A beta-induced MMP-9 responses in primary rat astrocytes. Our data show that apoE4 significantly dampens A beta-induced MMP-9 levels, possibly by downregulating the Rho-Rho kinase (ROCK) pathway. Reduction of astrocytic MMP-9 by apoE4 may affect A beta clearance and promote A beta deposition in AD. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：222 / 226

页数：5

共 32 条

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