Progress on new vaccine strategies against chronic viral infections

被引：99

作者：

Berzofsky, JA

Ahlers, JD

Janik, J

Morris, J

Oh, S

Terabe, M

Belyakov, IM

机构：

[1] NCI, Mol Immunogenet & Vaccine Res Sect, Vaccine Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[2] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA

[3] NCI, Clin Trials Team, Metab Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 04期

关键词：

D O I：

10.1172/JCI200422674

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for the vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses - quantitative and qualitative - than does the natural virus. Here we examine the immunologic and virologic basis for vaccines against three such viruses, HIV, hepatitis C virus, and human papillomavirus, and review progress in clinical trials to date. We also explore novel strategies for increasing the immunogenicity and efficacy of vaccines.

引用

收藏

页码：450 / 462

页数：13

相关论文

共 153 条

[1] Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence [J].

Ahlers, JD ;

Takeshita, T ;

Pendleton, CD ;

Berzofsky, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10856-10861

[2]

Ahlers JD, 1997, J IMMUNOL, V158, P3947

[3] Cytokine, chemokine, and costimulatory molecule modulation to enhance efficacy of HIV vaccines [J].

Ahlers, JD ;

Belyakov, IM ;

Berzofsky, JA .

CURRENT MOLECULAR MEDICINE, 2003, 3 (03) :285-301

[4] A push-pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L [J].

Ahlers, JD ;

Belyakov, IM ;

Terabe, M ;

Koka, R ;

Donaldson, DD ;

Thomas, EK ;

Berzofsky, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13020-13025

[5] High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection [J].

Ahlers, JD ;

Belyakov, IM ;

Thomas, EK ;

Berzofsky, JA .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (11) :1677-1685

[6] Mechanisms of cytokine synergy essential for vaccine protection against viral challenge [J].

Ahlers, JD ;

Belyakov, IM ;

Matsui, S ;

Berzofsky, JA .

INTERNATIONAL IMMUNOLOGY, 2001, 13 (07) :897-908

[7] Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy [J].

AlexanderMiller, MA ;

Leggatt, GR ;

Berzofsky, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :4102-4107

[8] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[9] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection [J].

Baba, TW ;

Liska, V ;

Hofmann-Lehmann, R ;

Vlasak, J ;

Xu, WD ;

Ayehunie, S ;

Cavacini, LA ;

Posner, MR ;

Katinger, H ;

Stiegler, G ;

Bernacky, BJ ;

Rizvi, TA ;

Schmidt, R ;

Hill, LR ;

Keeling, ME ;

Lu, YC ;

Wright, JE ;

Chou, TC ;

Ruprecht, RM .

NATURE MEDICINE, 2000, 6 (02) :200-206

[10] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].

Barouch, DH ;

Santra, S ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Wagner, W ;

Bilska, M ;

Craiu, A ;

Zheng, XX ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Nickerson, CE ;

Trigona, WL ;

Punt, K ;

Freed, DC ;

Guan, LM ;

Dubey, S ;

Casimiro, D ;

Simon, A ;

Davies, ME ;

Chastain, M ;

Strom, TB ;

Gelman, RS ;

Montefiori, DC ;

Lewis, MG ;

Emini, EA ;

Shiver, JW ;

Letvin, NL .

SCIENCE, 2000, 290 (5491) :486-492

← 1 2 3 4 5 6 7 8 9 10 →