Conservation of sequence and function in the Pax6 regulatory elements

被引：23

作者：

Morgan, R ^{[1
]}

机构：

[1] St George Hosp, Sch Med, Dept Basic Med Sci, London SW17 0RE, England

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 07期

关键词：

D O I：

10.1016/j.tig.2004.04.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Pax6 transcription factor is a highly conserved regulator of eye and brain development. Its complex mode of regulation is shared between Drosophila melanogaster and the vertebrates, despite there being no significant sequence identity between their enhancer and promoter regions. In this article, a more detailed examination of the Pax6 genomic sequence reveals a common set of putative Pax6 and basic helix-loop-helix transcription factor binding sites.

引用

页码：283 / 287

页数：5

共 24 条

[1] Conserved cis-regulatory modules mediate complex neural expression patterns of the eyeless gene in the Drosophila brain [J].

Adachi, Y ;

Hauck, B ;

Clements, J ;

Kawauchi, H ;

Kurusu, M ;

Totani, Y ;

Kang, YY ;

Eggert, T ;

Walldorf, U ;

Furukubo-Tokunaga, K ;

Callaerts, P .

MECHANISMS OF DEVELOPMENT, 2003, 120 (10) :1113-1126

[2] Differential Pax6 promoter activity and transcript expression during forebrain development [J].

Anderson, TR ;

Hedlund, E ;

Carpenter, EM .

MECHANISMS OF DEVELOPMENT, 2002, 114 (1-2) :171-175

[3]

Cai L, 2000, DEVELOPMENT, V127, P3021

[4] MUTATIONS IN THE CAENORHABDITIS-ELEGANS GENE VAB-3 REVEAL DISTINCT ROLES IN FATE SPECIFICATION AND UNEQUAL CYTOKINESIS IN AN ASYMMETRIC CELL-DIVISION [J].

CHAMBERLIN, HM ;

STERNBERG, PW .

DEVELOPMENTAL BIOLOGY, 1995, 170 (02) :679-689

[5] PATTERNING OF THE CAENORHABDITIS-ELEGANS HEAD REGION BY THE PAX-6 FAMILY MEMBER VAB-3 [J].

CHISHOLM, AD ;

HORVITZ, HR .

NATURE, 1995, 377 (6544) :52-55

[6]

Chow RL, 1999, DEVELOPMENT, V126, P4213

[7] New 3′ elements control Pax6 expression in the developing pretecturn, neural retina and olfactory region [J].

Griffin, C ;

Kleinjan, DA ;

Doe, B ;

van Heyningen, V .

MECHANISMS OF DEVELOPMENT, 2002, 112 (1-2) :89-100

[8] Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila [J].

Hauck, B ;

Gehring, WJ ;

Walldorf, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) :564-569

[9] MOUSE SMALL EYE RESULTS FROM MUTATIONS IN A PAIRED-LIKE HOMEOBOX-CONTAINING GENE [J].

HILL, RE ;

FAVOR, J ;

HOGAN, BLM ;

TON, CCT ;

SAUNDERS, GF ;

HANSON, IM ;

PROSSER, J ;

JORDAN, T ;

HASTIE, ND ;

VANHEYNINGEN, V .

NATURE, 1991, 354 (6354) :522-525

[10] The bHLH gene Hes1 regulates differentiation of multiple cell types [J].

Kageyama, R ;

Ohtsuka, T ;

Tomita, K .

MOLECULES AND CELLS, 2000, 10 (01) :1-7

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