Current therapy and novel agents for relapsed or refractory acute lymphoblastic leukemia

被引：28

作者：

Dinner, Shira ^{[1
]}

Lee, Daniel ^{[2
]}

Liedtke, Michaela ^{[1
]}

机构：

[1] Stanford Univ, Dept Med, Sch Med, Div Hematol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

来源：

LEUKEMIA & LYMPHOMA | 2014年 / 55卷 / 08期

关键词：

Acute lymphoblastic leukemia; salvage chemotherapy; immunotherapy; DOSE CYTOSINE-ARABINOSIDE; INOTUZUMAB OZOGAMICIN CMC-544; ACUTE LYMPHOCYTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; PHASE-I; INDUCTION THERAPY; ADULT PATIENTS; ONCOLOGY-GROUP; T-CELLS; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.3109/10428194.2013.856428

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite high rates of complete remission in newly diagnosed adult acute lymphoblastic leukemia (ALL), rates of long-term leukemia-free survival are disappointingly low. Treatment of relapsed disease with chemotherapy, even in patients able to pursue consolidation with allogeneic stem cell transplant, has demonstrated limited success. There are no established standards of care in this setting and few standard treatment options. Novel agents targeting antigens on the lymphoblast cell surface offer unique side effect and anti-leukemic profiles which suggest that their use alone or in combination with chemotherapy may achieve improved outcomes for relapsed or refractory ALL.

引用

页码：1715 / 1724

页数：10

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