Play down protein to play up metabolism?

被引：13

作者：

Mueller, Timo D. ^{[1
]}

Tschoep, Matthias H. ^{[1
,2
]}

机构：

[1] Helmholtz Ctr Munich, IDO, Munich, Germany

[2] Tech Univ Munich, Dept Med, Div Metab Dis, D-80290 Munich, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 09期

关键词：

PPAR-ALPHA; FIBROBLAST-GROWTH-FACTOR-21; INDUCTION; PATHWAY; FGF-21; RATS; GUT;

D O I：

10.1172/JCI77508

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Who among us hasn't fantasized about a diet that allows ingestion of a surfeit of calories that are burned off effortlessly by ramping up energy expenditure? In this issue of the JCI, research led by Christopher Morrison suggests that this dream may become a reality; however, a complete understanding of the molecular interface that connects nutrient choices with our cellular metabolism will be required. Laeger et al. show that the expression and secretion of the weight-reducing hormone fibroblast growth factor 21 (FGF21) is regulated by dietary proteins and not, as has been heretofore assumed, simply triggered by reduced caloric intake. This study not only sheds new light on the role of FGF21 in systems metabolism, but also on the ways our bodies cope with the ever-changing availability of different dietary macronutrients.

引用

页码：3691 / 3693

页数：3

共 14 条

[1]

Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002

[2] Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein [J].

Bielohuby, Maximilian ;

Menhofer, Dominik ;

Kirchner, Henriette ;

Stoehr, Barbara J. M. ;

Mueller, Timo D. ;

Stock, Peggy ;

Hempel, Madlen ;

Stemmer, Kerstin ;

Pfluger, Paul T. ;

Kienzle, Ellen ;

Christ, Bruno ;

Tschoep, Matthias H. ;

Bidlingmaier, Martin .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2011, 300 (01) :E65-E76

[3] Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway [J].

Chau, Mary D. L. ;

Gao, Jiaping ;

Yang, Qing ;

Wu, Zhidan ;

Gromada, Jesper .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (28) :12553-12558

[4] Mu-Opioid Receptors and Dietary Protein Stimulate a Gut-Brain Neural Circuitry Limiting Food Intake [J].

Duraffourd, Celine ;

De Vadder, Filipe ;

Goncalves, Daisy ;

Delaere, Fabien ;

Penhoat, Armelle ;

Brusset, Bleuenn ;

Rajas, Fabienne ;

Chassard, Dominique ;

Duchampt, Adeline ;

Stefanutti, Anne ;

Gautier-Stein, Amandine ;

Mithieux, Gilles .

CELL, 2012, 150 (02) :377-388

[5] FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis [J].

Fisher, Ffolliott M. ;

Kleiner, Sandra ;

Douris, Nicholas ;

Fox, Elliott C. ;

Mepani, Rina J. ;

Verdeguer, Francisco ;

Wu, Jun ;

Kharitonenkov, Alexei ;

Flier, Jeffrey S. ;

Maratos-Flier, Eleftheria ;

Spiegelman, Bruce M. .

GENES & DEVELOPMENT, 2012, 26 (03) :271-281

[6] Fibroblast Growth Factor 21 Levels in Young Healthy Females Display Day and Night Variations and Are Increased in Response to Short-Term Energy Deprivation Through a Leptin-Independent Pathway [J].

Foo, Joo-Pin ;

Aronis, Konstantinos N. ;

Chamberland, John P. ;

Paruthi, Jason ;

Moon, Hyun-Seuk ;

Mantzoros, Christos S. .

DIABETES CARE, 2013, 36 (04) :935-942

[7] Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21 [J].

Inagaki, Takeshi ;

Dutchak, Paul ;

Zhao, Guixiang ;

Ding, Xunshan ;

Gautron, Laurent ;

Parameswara, Vinay ;

Li, Yong ;

Goetz, Regina ;

Mohammadi, Moosa ;

Esser, Victoria ;

Elmquist, Joel K. ;

Gerard, Robert D. ;

Burgess, Shawn C. ;

Hammer, Robert E. ;

Mangelsdorf, David J. ;

Kliewer, Steven A. .

CELL METABOLISM, 2007, 5 (06) :415-425

[8] FGF-21 as a novel metabolic regulator [J].

Kharitonenkov, A ;

Shiyanova, TL ;

Koester, A ;

Ford, AM ;

Micanovic, R ;

Galbreath, EJ ;

Sandusky, GE ;

Hammond, LJ ;

Moyers, JS ;

Owens, RA ;

Gromada, J ;

Brozinick, JT ;

Hawkins, ED ;

Wroblewski, VJ ;

Li, DS ;

Mehrbod, F ;

Jaskunas, SR ;

Shanafelt, AB .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1627-1635

[9] FGF21 is an endocrine signal of protein restriction [J].

Laeger, Thomas ;

Henagan, Tara M. ;

Albarado, Diana C. ;

Redman, Leanne M. ;

Bray, George A. ;

Noland, Robert C. ;

Muenzberg, Heike ;

Hutson, Susan M. ;

Gettys, Thomas W. ;

Schwartz, Michael W. ;

Morrison, Christopher D. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (09) :3913-3922

[10] Identification of a novel FGF, FGF-21, preferentially expressed in the liver [J].

Nishimura, T ;

Nakatake, Y ;

Konishi, M ;

Itoh, N .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2000, 1492 (01) :203-206

← 1 2 →