Efficacy of the combination ampicillin plus ceftriaxone in the treatment of a case of enterococcal endocarditis due to Enterococcus faecalis highly resistant to gentamicin:: Efficacy of the "ex vivo" synergism method

被引：10

作者：

Tascini, C ^{[1
]}

Doria, R ^{[1
]}

Leonildi, A ^{[1
]}

Martinelli, C ^{[1
]}

Menichetti, F ^{[1
]}

机构：

[1] Univ Pisa, Div Infect Dis, Pisa, Italy

来源：

JOURNAL OF CHEMOTHERAPY | 2004年 / 16卷 / 04期

关键词：

endocarditis; enterococcus faecalis endocarditis; ampicillin; ceftriaxone;

D O I：

10.1179/joc.2004.16.4.400

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The case of a patient with highly gentamicin-resistant Enterococcus faecalis endocarditis treated with an ampicillin + ceftriaxone combination is described. We have designed a method to evaluate synergism between the antibacterial activity of patient's serum taken during a given antibiotic regimen (ampicillin) to which another antibiotic (ceftriaxone) is added in vitro. In this patient the two-drug combination was able to stop the bacteremia and prevent the infection of the prosthetic valve.

引用

页码：400 / 403

页数：4

共 14 条

[1] INFLUENCE OF HIGH-LEVEL GENTAMICIN RESISTANCE AND BETA-HEMOLYSIS ON SUSCEPTIBILITY OF ENTEROCOCCI TO THE BACTERICIDAL ACTIVITIES OF AMPICILLIN AND VANCOMYCIN [J].