Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells

被引：12

作者：

Dai Hung Ngo ^{[1
]}

Dai Nghiep Ngo ^{[2
]}

Kim, Se-Kwon ^{[3
]}

Thanh Sang Vo ^{[4
]}

机构：

[1] Thu Dau Mot Univ, Fac Nat Sci, Thu Dau Mot City 820000, Binh Duong Prov, Vietnam

[2] Vietnam Natl Univ, Univ Sci, Fac Biol & Biotechnol, Dept Biochem, Ho Chi Minh City 700000, Vietnam

[3] Korea Maritime & Ocean Univ, Coll Ocean Sci & Technol, Dept Marine Life Sci, Busan 606791, South Korea

[4] Nguyen Tat Thanh Univ, NTT Hitech Inst, Ho Chi Minh City, Vietnam

来源：

BIOMOLECULES | 2019年 / 9卷 / 05期

关键词：

chitooligosaccharide; proliferation; apoptosis; A549; cells; caspase-3; DOWN-REGULATION; INHIBIT; PROLIFERATION; INVASION; CHITOSAN; COS;

D O I：

10.3390/biom9050195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aminoethyl-chitooligosaccharide (AE-COS) was reported to inhibit human gastric cancer cell proliferation and human fibrosarcoma cell invasion. In this study, the role of AE-COS in down-regulation of proliferation of human lung A549 cancer cells was evaluated. It was found that AE-COS was able to reduce A549 cell proliferation to (32 +/- 1.3)% at a concentration of 500 mu g/mL. Moreover, AE-COS treatment caused suppression on COX-2 expression in a dose-dependent manner. Notably, the role of AE-COS in induction of cell apoptosis was observed via decreasing Bcl-2 expression and increasing caspase-3 and -9 activation. Accordingly, the antiproliferative effect of AE-COS was indicated due to suppression of cell proliferation and induction of cell apoptosis, suggesting AE-COS as a promising chemotherapy agent for treatment of lung cancer.

引用

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