2-Pyridonate Tantalum Complexes for the Intermolecular Hydroaminoalkylation of Sterically Demanding Alkenes

被引：63
作者：
Chong, Eugene [1 ]
Brandt, Jason W. [1 ]
Schafer, Laurel L. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 31期
基金：
加拿大自然科学与工程研究理事会;
关键词：
TITANIUM-CATALYZED HYDROAMINOALKYLATION; C(SP(3))-H ALPHA-ALKYLATION; H BOND ACTIVATION; NITROGEN ATOM; UNACTIVATED OLEFINS; AMIDATE COMPLEXES; SECONDARY-AMINES; SUBSTRATE SCOPE; HYDROAMINATION; ADJACENT;
D O I：
10.1021/ja506187m
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The design and synthesis of a mixed 2-pyridonate-Ta(NMe2)(3)Cl complex for the direct C-H alkylation adjacent to nitrogen in unprotected secondary amines are reported. The hydroaminoalkylation of sterically demanding internal alkenes gives the direct, catalytic formation of C(sp(3))-C(sp(3)) bonds. Substrate scope investigations reveal key strategies for further catalyst development efforts in this 100% atom-economic synthesis of alpha-alkylated amines.
引用
收藏
页码：10898 / 10901
页数：4
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