Synthesis of Isoxazolo[5,4-b]pyridines by Microwave-Assisted Multi-Component Reactions in Water

被引：76

作者：

Tu, Shu-Jiang ^{[1
]}

Zhang, Xiao-Hong ^{[1
]}

Han, Zheng-Guo ^{[1
]}

Cao, Xu-Dong ^{[1
]}

Wu, Shan-Shan ^{[1
]}

Yan, Shu ^{[1
]}

Hao, Wen-Juan ^{[1
]}

Zhang, Ge ^{[1
]}

Ma, Ning ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Key Lab Biotechnol Med Plant, Xuzhou 221116, Jiangsu, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2009年 / 11卷 / 03期

基金：

美国国家科学基金会;

关键词：

COMBINATORIAL LIBRARY SYNTHESIS; PHASE ORGANIC-REACTIONS; COMPREHENSIVE SURVEY; CHEMISTRY; DERIVATIVES; AMINES; POTENT;

D O I：

10.1021/cc800212v

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.

引用

页码：428 / 432

页数：5

共 30 条

[1] Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach
Chande, MS
Verma, RS
Barve, PA
Khanwelkar, RR
Vaidya, RB
Ajaikumar, KB
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (11) : 1143 - 1148
[2] Catalyst-free chemoselective N-tert-butyloxycarbonylation of amines in water
Chankeshwara, Sunay V.
Chakraborti, Asit K.
[J]. ORGANIC LETTERS, 2006, 8 (15) : 3259 - 3262
[3] Microwave-assisted synthesis in water as solvent
Dallinger, Doris
Kappe, C. Oliver
[J]. CHEMICAL REVIEWS, 2007, 107 (06) : 2563 - 2591
[4] DANNHARDT G, 1993, ARZNEIMITTEL-FORSCH, V43-1, P441
[5] SELECTIVE INHIBITORS OF PROTEIN-KINASE-C IN A MODEL OF GRAFT-VS-HOST DISEASE
DEMERS, JP
HAGEMAN, WE
JOHNSON, SG
KLAUBERT, DH
LOOK, RA
MOORE, JB
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (20) : 2451 - 2456
[6] Comprehensive survey of combinatorial library synthesis: 1999
Dolle, RE
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (05): : 383 - 433
[7] Comprehensive survey of combinatorial library synthesis: 1998
Dolle, RE
Nelson, KH
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (04): : 235 - 282
[8] Rapid microwave-promoted synthesis of new sulfonylmethylbenzothiazoles in water
Gellis, A
Boufatah, N
Vanelle, P
[J]. GREEN CHEMISTRY, 2006, 8 (05) : 483 - 487
[9] Reaction solvent selection: The potential of water as a solvent for organic transformations
Hailes, Helen C.
[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2007, 11 (01) : 114 - 120
[10] Solid-phase organic reactions: A review of the recent literature
Hermkens, PHH
Ottenheijm, HCJ
Rees, D
[J]. TETRAHEDRON, 1996, 52 (13) : 4527 - 4554

← 1 2 3 →