Synthesis of Isoxazolo[5,4-b]pyridines by Microwave-Assisted Multi-Component Reactions in Water

被引：76

作者：

Tu, Shu-Jiang ^{[1
]}

Zhang, Xiao-Hong ^{[1
]}

Han, Zheng-Guo ^{[1
]}

Cao, Xu-Dong ^{[1
]}

Wu, Shan-Shan ^{[1
]}

Yan, Shu ^{[1
]}

Hao, Wen-Juan ^{[1
]}

Zhang, Ge ^{[1
]}

Ma, Ning ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Key Lab Biotechnol Med Plant, Xuzhou 221116, Jiangsu, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2009年 / 11卷 / 03期

基金：

美国国家科学基金会;

关键词：

COMBINATORIAL LIBRARY SYNTHESIS; PHASE ORGANIC-REACTIONS; COMPREHENSIVE SURVEY; CHEMISTRY; DERIVATIVES; AMINES; POTENT;

D O I：

10.1021/cc800212v

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.

引用

收藏

页码：428 / 432

页数：5

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