The Brown Norway rats and the kinin system

被引：26
作者：
Damas, J
机构：
[1] Departement of Human Physiology, University of Liège, B-4020 Liège
来源：
PEPTIDES | 1996年 / 17卷 / 05期
关键词：
kininogen deficiency; kidney; hypertension; inflammation; cardiovascular shock;
D O I：
10.1016/0196-9781(96)00056-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In 1979, we found a strain of kininogen-deficient Brown Norway rats. Since then, several studies have used these animals as negative controls of the involvement of the kinin system in physiological and pathophysiological processes. The cause of this deficiency has now been elucidated. This article reviews studies performed with these kininogen-deficient rats. These investigations have mainly focused on the links between the kinin system and the kidneys, hypertension, salivary glands, acute inflammatory reactions, cysteine proteinase inhibition, lymphatic tissues, coagulation, and cardiovascular shock states.
引用
收藏
页码：859 / 872
页数：14
相关论文
共 182 条
[1]   QUANTIFICATION OF RAT T-KININOGEN USING IMMUNOLOGICAL METHODS - APPLICATION TO INFLAMMATORY PROCESSES [J].
ADAM, A ;
DAMAS, J ;
CALAY, G ;
RENARD, C ;
REMACLEVOLON, G ;
BOURDON, V .
BIOCHEMICAL PHARMACOLOGY, 1989, 38 (10) :1569-1575
[2]  
ADAM A, 1986, British Journal of Pharmacology, V89, p589P
[3]   PURIFICATION AND CHARACTERIZATION OF PLASMA T-KININOGEN FROM WISTAR AND BROWN NORWAY RATS [J].
ADAM, A ;
DAMAS, J ;
RENARD, C ;
CALAY, G ;
BOURDON, V .
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1989, 67 (2-3) :86-92
[4]   MEASUREMENT OF URINARY KALLIKREIN ACTIVITY - SPECIES-DIFFERENCES IN KININ PRODUCTION [J].
ALHENCGELAS, F ;
MARCHETTI, J ;
ALLEGRINI, J ;
CORVOL, P ;
MENARD, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 677 (3-4) :477-488
[5]   PARASYMPATHETIC NONADRENERGIC, NONCHOLINERGIC REFLEX SECRETION OF PAROTID ACINAR GRANULES IN RATS PRETREATED WITH ATROPINE AND ADRENOCEPTOR ANTAGONISTS [J].
ASZTELY, A ;
TOBIN, G ;
EKSTROM, J .
REGULATORY PEPTIDES, 1994, 51 (03) :255-262
[6]  
Bao G, 1992, Agents Actions Suppl, V38 ( Pt 2), P423
[7]   ROLE OF BRADYKININ IN CHRONIC ANTIHYPERTENSIVE ACTIONS OF RAMIPRIL IN DIFFERENT HYPERTENSION MODELS [J].
BAO, G ;
GOHLKE, P ;
UNGER, T .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1992, 20 :S96-S99
[8]   T-KININOGEN - THE MAJOR PLASMA KININOGEN IN RAT ADJUVANT ARTHRITIS [J].
BARLAS, A ;
OKAMOTO, H ;
GREENBAUM, LM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 129 (01) :280-286
[9]   ISOLATION OF A THIOL-ACTIVATED T-KININOGENASE FROM THE RAT SUBMANDIBULAR-GLAND [J].
BARLAS, A ;
GAO, XX ;
GREENBAUM, LM .
FEBS LETTERS, 1987, 218 (02) :266-270
[10]   RELEASE OF T-KININ AND BRADYKININ IN CARRAGEENIN INDUCED INFLAMMATION IN THE RAT [J].
BARLAS, A ;
SUGIO, K ;
GREENBAUM, LM .
FEBS LETTERS, 1985, 190 (02) :268-270
12345678910