Synthesis and antimicrobial activity of new quaternary ammonium chlorides

被引：7
作者：
Brycki, B
Skrzypczak, A
Mirska, I
Pernak, J
机构：
[1] POZNAN TECH UNIV,PL-60965 POZNAN,POLAND
[2] POZNAN TECH UNIV,SCH MED SCI,DEPT PHARMACEUT BACTERIOL,PL-61771 POZNAN,POLAND
来源：
ARCHIV DER PHARMAZIE | 1996年 / 329卷 / 06期
关键词：
quaternary ammonium chlorides; alkoxymethyldecyldimethylammonium chlorides alkylthiomethyldecyl-dimethylammonium chloride; antimicrobial activity; structure-activity-relationships;
D O I：
10.1002/ardp.19963290603
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Decyldimethylamine reacts readily with chloromethylalkyl ethers or sulfides, chloromethylbenzyl ethers or sulfides and chloromethylcycloalkyl ethers to give quaternary ammonium chlorides in very good yields. All the chlorides studied showed antimicrobial activity. The relationship between the chemical structure and antimicrobial activity was analyzed by rough sets.
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页码：279 / 282
页数：4
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