Direct-acting antiviral treatment for patients with hepatocellular carcinoma

被引：11

作者：

Kushner, Tatyana ^{[1
]}

Dieterich, Douglas ^{[1
]}

Saberi, Behnam ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Div Liver Dis, 1425 Madison Ave,Room 11-70,Box 1123, New York, NY 10029 USA

来源：

CURRENT OPINION IN GASTROENTEROLOGY | 2018年 / 34卷 / 03期

关键词：

Direct-acting antivirals; hepatitis C virus; hepatocellular carcinoma; liver transplant; HEPATITIS-C VIRUS; SUSTAINED VIROLOGICAL RESPONSE; EARLY TUMOR RECURRENCE; RADIOFREQUENCY ABLATION; LIVER-TRANSPLANTATION; THERAPY; INFECTION; IMPACT; ERADICATION; SOFOSBUVIR;

D O I：

10.1097/MOG.0000000000000431

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose of ReviewHepatocellular carcinoma (HCC) affects a significant portion of patients with hepatitis C. The use of direct-acting antiviral (DAA) agents has transformed the disease outcomes in this patient group.Recent FindingsHepatitis C virus (HCV) response to DAAs can be affected by the presence of HCC, whereas DAA therapy may affect the risk of HCC recurrence in patients with a history of HCC.SummaryEmerging data are demonstrating lower sustained virologic response (SVR) rates in patients with HCC compared with patients without HCC. Conflicting studies have also suggested that rates of HCC recurrence in patients with a history of HCC can potentially be increased or decreased on DAA therapy. This review will provide a brief overview of these data and inform practitioners on important considerations to make when prescribing DAA therapy for patients with HCV and HCC.

引用

页码：132 / 139

页数：8

共 37 条

[1] Pre- Versus Posttransplant Treatment of Hepatitis C Virus With Direct-Acting Antivirals in Liver Transplant Recipients: More Issues to be Solved [J].

Abdelqader, Abdelhai ;

Kabacam, Gokhan ;

Woreta, Tinsay A. ;

Hamilton, James P. ;

Luu, Harry ;

Al Khalloufi, Kawtar ;

Saberi, Behnam ;

Philosophe, Benjamin ;

Cameron, Andrew M. ;

Gurakar, Ahmet .

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 2017, 15 :1-5

[2]

[Anonymous], J HEPATOL

[3] Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals [J].

Baumert, Thomas F. ;

Juehling, Frank ;

Ono, Atsushi ;

Hoshida, Yujin .

BMC MEDICINE, 2017, 15

[4] Effectiveness of hepatitis C antiviral treatment in a USA cohort of veteran patients with hepatocellular carcinoma [J].

Beste, Lauren A. ;

Green, Pamela K. ;

Berry, Kristin ;

Kogut, Matthew J. ;

Allison, Stephen K. ;

Ioannou, George N. .

JOURNAL OF HEPATOLOGY, 2017, 67 (01) :32-39

[5] Is early recurrence of hepatocellular carcinoma in HCV cirrhotic patients affected by treatment with direct-acting antivirals? A prospective multicentre study [J].

Cabibbo, G. ;

Petta, S. ;

Calvaruso, V. ;

Cacciola, I. ;

Cannavo, M. R. ;

Madonia, S. ;

Distefano, M. ;

Larocca, L. ;

Prestileo, T. ;

Tine, F. ;

Bertino, G. ;

Giannitrapani, L. ;

Benanti, F. ;

Licata, A. ;

Scalisi, I. ;

Mazzola, G. ;

Cartabellotta, F. ;

Alessi, N. ;

Barbara, M. ;

Russello, M. ;

Scifo, G. ;

Squadrito, G. ;

Raimondo, G. ;

Craxi, A. ;

Di Marco, V. ;

Camma, C. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2017, 46 (07) :688-695

[6] Predictive factors associated with hepatitis C antiviral therapy response [J].

Cavalcante, Lourianne Nascimento ;

Lyra, Andre Castro .

WORLD JOURNAL OF HEPATOLOGY, 2015, 7 (12) :1617-1631

[7] Optimal Timing of Hepatitis C Treatment for Patients on the Liver Transplant Waiting List [J].

Chhatwal, Jagpreet ;

Samur, Sumeyye ;

Kues, Brian ;

Ayer, Turgay ;

Roberts, Mark S. ;

Kanwal, Fasiha ;

Hur, Chin ;

Donnell, Drew Michael S. ;

Chung, Raymond T. .

HEPATOLOGY, 2017, 65 (03) :777-788

[8] Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals [J].

Conti, Fabio ;

Buonfiglioli, Federica ;

Scuteri, Alessandra ;

Crespi, Cristina ;

Bolondi, Luigi ;

Caraceni, Paolo ;

Foschi, Francesco Giuseppe ;

Lenzi, Marco ;

Mazzella, Giuseppe ;

Verucchi, Gabriella ;

Andreone, Pietro ;

Brillanti, Stefano .

JOURNAL OF HEPATOLOGY, 2016, 65 (04) :727-733

[9] Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection After Liver Transplantation: An Open-Label Study [J].

Curry, Michael P. ;

Forns, Xavier ;

Chung, Raymond T. ;

Terrault, Norah A. ;

Brown, Robert, Jr. ;

Fenkel, Jonathan M. ;

Gordon, Fredric ;

O'Leary, Jacqueline ;

Kuo, Alexander ;

Schiano, Thomas ;

Everson, Gregory ;

Schiff, Eugene ;

Befeler, Alex ;

Gane, Edward ;

Saab, Sammy ;

McHutchison, John G. ;

Subramanian, G. Mani ;

Symonds, William T. ;

Denning, Jill ;

McNair, Lindsay ;

Arterburn, Sarah ;

Svarovskaia, Evguenia ;

Moonka, Dilip ;

Afdhal, Nezam .

GASTROENTEROLOGY, 2015, 148 (01) :100-U519

[10] A Clinician's Guide to Drug-Drug Interactions With Direct-Acting Antiviral Agents for the Treatment of Hepatitis C Viral Infection [J].

Dick, Travis B. ;

Lindberg, Lance S. ;

Ramirez, Debra D. ;

Charlton, Michael R. .

HEPATOLOGY, 2016, 63 (02) :634-643

← 1 2 3 4 →