Synthesis and hypoglycaemic activity of some new flavone derivatives - Part 1: Flavonylsulphonylurea derivatives

被引：0

作者：

Bozdag, O

Verspohl, EJ

Ertan, R ^{[1
]}

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Univ Munster, Inst Med Chem, Dept Pharmacol, D-48149 Munster, Germany

来源：

ARCHIV DER PHARMAZIE | 1999年 / 332卷 / 12期

关键词：

flavone; hypoglycaemic activity; flavonylsulphonylurea;

D O I：

10.1002/(SICI)1521-4184(199912)332:12<435::AID-ARDP435>3.0.CO;2-L

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of flavonyl-3'-sulphonylurea derivatives (1-7) was prepared by reaction of several isocyanates with flavone-3'-sulpholamide (III). The prepared compounds were tested for their insulinotropic activities in INS-I cells. Compounds 1 and 4 were able to increase insulin release in the presence of 8.3 mM glucose pat least at the higher concentrations used.

引用

页码：435 / 438

页数：4

共 12 条

[1] ISOLIQUIRITIGENIN - A NEW ALDOSE REDUCTASE INHIBITOR FROM GLYCYRRHIZAE RADIX [J].