Ratiometric Single-Nanoparticle Oxygen Sensors for Biological Imaging

被引：338
作者：
Wu, Changfeng [1 ]
Bull, Barbara [1 ]
Christensen, Kenneth [1 ]
McNeill, Jason [1 ]
机构：
[1] Clemson Univ, Dept Chem, Clemson, SC 29634 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 15期
关键词：
fluorescent probes; FRET; nanostructures; polymers; sensors; CONJUGATED POLYMER NANOPARTICLES; TRANSITION-METAL COMPLEXES; OPTICAL NANOSENSORS; ROOM-TEMPERATURE; MOLECULAR-OXYGEN; ENERGY-TRANSFER; LIVING CELLS; FLUORESCENCE; HYPOXIA; PHOSPHORESCENCE;
D O I：
10.1002/anie.200805894
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It makes sense: Conjugated polymer nanoparticles doped with a platinum porphyrin dye exhibit bright phosphorescence that is highly sensitive to the concentration of molecular oxygen. The small size, extraordinary brightness, excellent sensitivity, and ratiometric emission, together with the demonstration of single-particle sensing and cellular uptake, indicate the potential of the nanoparticle sensors for quantitative mapping of local molecular oxygen concentration. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2741 / 2745
页数：5
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