During 2 years, a melon crop (Cucumis melo L. cv. Sancho) was grown under field conditions to investigate the effects of different nitrogen (N) and irrigation (I) levels on fruit yield, fruit quality, irrigation water use efficiency (IWUE) and nitrogen applied efficiency (NAE). The statistical design was a split-plot with four replications, where irrigation was the main factor of variation and N was the secondary factor. In 2005, irrigation treatments consisted of applying daily a moderate water stress equivalent to 75% of ETc (crop evapotranspiration), a 100% ETc control and an excess irrigation of 125% ETc (designated as I-75, I-100 and I-125), while the N treatments were 30, 85,112 and 139 kg N ha(-1)(designated as N-30, N-85, N-112 and N-139). In 2006, both the irrigation and N treatments applied were: 60, 100 and 140% ETc (I-60, I-100 and I-140) and 93, 243 and 393 kg N ha(-1) (N-93, N-243 and N-393). Moderate water stress did not reduce melon yield and high IWUE was obtained. Under severe deficit irrigation, the yield was reduced by 22% mainly due to decrease fruit weight. The relative yield (yield/maximum yield) was higher than 95% when the irrigation depth applied was in the range of 87-136% ETc. In 2006, the interaction between irrigation and N was significant for yield, fruit weight and IWUE. The best yield, 41.3 Mg ha(-1), was obtained with 100% ETc at N93. The flesh firmness and the placenta and seeds weight increased when the irrigation level was reduced by 60% ETc. The highest NAE was obtained with quantities of water close to 100% ETc and increased as the N level was reduced. The highest IWUE was obtained with applications close to 90 kg N ha(-1). The I-243 and I-393 treatments produced inferior fruits due to higher skin ratios and lower flesh ratios. These results suggest that it is possible to apply moderate deficit irrigation, around 90% ETc, and reduce nitrogen input to 90 kg ha(-1) without lessening quality and yields. (C) 2008 Elsevier B.V. All rights reserved.