Bioelectric effect and bacterial biofilms. A systematic review

被引：111

作者：

Del Pozo, J. L. ^{[2
,3
]}

Rouse, M. S. ^{[2
,3
]}

Patel, R. ^{[1
,2
,3
]}

机构：

[1] Mayo Clin, Div Clin Microbiol, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[2] Mayo Clin, Infect Dis Res Lab, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Med, Div Infect Dis, Rochester, MN 55905 USA

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2008年 / 31卷 / 09期

关键词：

Bioelectric effect; Biofilm;

D O I：

10.1177/039139880803100906

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Bacteria growing in biofilms cause a wide range of human infections. Biofilm bacteria are resistant to antimicrobics at levels 500 to 5,000 times higher than those needed to kill nonbiofilm bacteria. In vitro experiments have shown that electric current can enhance the activity of some antimicrobial agents against certain bacteria in biofilms; this has been termed the "bioelectric effect". Direct electrical current has already been safely used in humans for fracture healing. Application of direct electric current with antimicrobial chemotherapy in humans could theoretically abrogate the need to remove the device in device-related infections, a procedure associated with substantial morbidity and cost. In this article, we review what has been described in the literature with regards to the bioelectric effect. (Int J Artif Organs 2008; 31: 786-95)

引用

页码：786 / 795

页数：10

共 44 条

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