In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria

被引：87
作者：
Braunstein, A [1 ]
Papo, N [1 ]
Shai, Y [1 ]
机构：
[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 08期
关键词：
D O I：
10.1128/AAC.48.8.3127-3129.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% D amino acids) of an antimicrobial peptide, K6L9 (LKLLKKLLKKLLKLL-NH2), but not the all-L-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomonas aeruginosa and gentamicin-resistant Acinetobacter baumannii bacteria. Various biophysical experiments suggest a membranolytic-like effect.
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页码：3127 / 3129
页数：3
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