Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216

被引：12

作者：

Kimura, Toru ^{[1
]}

Inahashi, Yuki ^{[1
,2
]}

Matsuo, Hirotaka ^{[1
,2
]}

Suga, Takuya ^{[1
,2
]}

Iwatsuki, Masato ^{[1
,2
]}

Shiomi, Kazuro ^{[1
,2
]}

Takahashi, Yoko ^{[2
]}

Omura, Satoshi ^{[2
]}

Nakashima, Takuji ^{[1
,2
]}

机构：

[1] Kitasato Univ, Grad Sch Infect Control Sci, Tokyo, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Tokyo, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 06期

关键词：

ANTITRYPANOSOMAL ACTIVITY; ACTINOMYCETE; MANGROMICINS;

D O I：

10.1038/s41429-018-0038-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.

引用

页码：606 / 608

页数：3

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