Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis

被引：21

作者：

Kawashiri, Shin-ya ^{[1
,2
]}

Suzuki, Takahisa ^{[2
]}

Nakashima, Yoshikazu ^{[2
]}

Horai, Yoshiro ^{[2
]}

Okada, Akitomo ^{[2
]}

Nishino, Ayako ^{[2
]}

Iwamoto, Naoki ^{[2
]}

Ichinose, Kunihiro ^{[2
]}

Arima, Kazuhiko ^{[1
]}

Tamai, Mami ^{[3
]}

Nakamura, Hideki ^{[2
]}

Origuchi, Tomoki ^{[4
]}

Uetani, Masataka ^{[5
]}

Aoyagi, Kiyoshi ^{[1
]}

Eguchi, Katsumi ^{[6
]}

Kawakami, Atsushi ^{[2
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Publ Hlth, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Immunol & Rheumatol, Nagasaki 8528501, Japan

[3] Nagasaki Univ, Ctr Hlth & Community Med, Nagasaki 8528501, Japan

[4] Nagasaki Univ, Grad Sch Biomed Sci, Dept Hlth Sci, Nagasaki 8528501, Japan

[5] Nagasaki Univ, Grad Sch Biomed Sci, Dept Radiol Sci, Nagasaki 8528501, Japan

[6] Sasebo City Gen Hosp, Dept Internal Med, Sasebo, Japan

来源：

RHEUMATOLOGY | 2014年 / 53卷 / 08期

关键词：

rheumatoid arthritis; ultrasonography; magnetic resonance imaging; synovitis; osteitis; FINGER JOINTS; BONE EDEMA; WRISTS;

D O I：

10.1093/rheumatology/keu034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. The aim of this study was to explore whether assessment of synovial inflammation by ultrasonography correlates with MRI-proven osteitis in patients with RA. Methods. Thirty RA patients who fulfilled 2010 RA classification criteria and were naive to DMARDs, including biologics and glucocorticoids, were consecutively enrolled in this study. Grey scale (GS) and power Doppler (PD) images of articular synovitis and bone erosion in both wrist and MCP joints were evaluated by the method proposed by the European League Against Rheumatism. MRI-proven osteitis of the identical sites was also evaluated within 3 days using the RA MRI scoring system (RAMRIS). The Cochran-Armitage test and Spearman's correlation coefficient were used to investigate the correlation of each US finding with MRI-proven osteitis. Results. MRI-proven osteitis was found in 8.3% of MCP joints and 48.3% of wrist joints. Its prevalence was increased in the joints where the GS or PD grade of articular synovitis was 2 or 3. In addition, MRI-proven osteitis was found preferentially in the joints positive for bone erosion on US. A clear correlation was demonstrated between the GS or PD grade of articular synovitis or the presence of US bone erosion and RAMRIS osteitis score in both MCP joints and wrist joints. Conclusion. Our data indicate that joint injury assessed by US correlates with MRI-proven osteitis in patients with RA.

引用

页码：1452 / 1456

页数：5

共 17 条

[1]

Aletaha D, 2010, ANN RHEUM DIS, V69, P1580, DOI [10.1136/ard.2010.138461, 10.1002/art.27584]

[2] Guidelines for musculoskeletal ultrasound in rheumatology [J].

Backhaus, M ;

Burmester, GR ;

Gerber, T ;

Grassi, W ;

Machold, KP ;

Swen, WA ;

Wakefield, RJ ;

Manger, B .

ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (07) :641-649

[3] EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis [J].

Colebatch, Alexandra N. ;

Edwards, Christopher John ;

Ostergaard, Mikkel ;

van der Heijde, Desiree ;

Balint, Peter V. ;

D'Agostino, Maria-Antonietta ;

Forslind, Kristina ;

Grassi, Walter ;

Haavardsholm, Espen A. ;

Haugeberg, Glenn ;

Jurik, Anne-Grethe ;

Landewe, Robert B. M. ;

Naredo, Esperanza ;

O'Connor, Philip J. ;

Ostendorf, Ben ;

Potocki, Kristina ;

Schmidt, Wolfgang A. ;

Smolen, Josef S. ;

Sokolovic, Sekib ;

Watt, Iain ;

Conaghan, Philip G. .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (06) :804-814

[4] Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease [J].

Dalbeth, N. ;

Smith, T. ;

Gray, S. ;

Doyle, A. ;

Antill, P. ;

Lobo, M. ;

Robinson, E. ;

King, A. ;

Cornish, J. ;

Shalley, G. ;

Gao, A. ;

McQueen, F. M. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (02) :279-282

[5] The role of RANK ligand/osteoprotegerin in rheumatoid arthritis [J].

Geusens, Piet .

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 2012, 4 (04) :225-233

[6] Examination of intra and interrater reliability with a new ultrasonographic reference atlas for scoring of synovitis in patients with rheumatoid arthritis [J].

Hammer, Hilde Berner ;

Bolton-King, Pernille ;

Bakkeheim, Vivi ;

Berg, Torill Helene ;

Sundt, Elisabeth ;

Kongtorp, Anne Katrine ;

Haavardsholm, Espen A. .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (11) :1995-1998

[7]

Kawashiri SY, 2012, MOD RHEUMATOL, V23, P36

[8] The use of MRI in early RA [J].

McQueen, F. M. .

RHEUMATOLOGY, 2008, 47 (11) :1597-1599

[9] Assessment of inflammatory activity in rheumatoid arthritis: a comparative study of clinical evaluation with grey scale and power Doppler ultrasonography [J].

Naredo, E ;

Bonilla, G ;

Gamero, F ;

Uson, J ;

Carmona, L ;

Laffon, A .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (03) :375-381

[10]

Ostergaard M, 2003, J RHEUMATOL, V30, P1385

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