Application of high-throughput sequencing in understanding human oral microbiome related with health and disease

被引:262
作者
Chen, Hui [1 ]
Jiang, Wen [1 ]
机构
[1] Zhejiang Univ, Coll Med, Affiliated Hosp Stomatol, Dept Conservat Dent & Periodont, Hangzhou 310006, Zhejiang, Peoples R China
来源
FRONTIERS IN MICROBIOLOGY | 2014年 / 5卷
关键词
oral microbiome; high-throughput sequencing; dental caries; periodontitis; apical periodontitis; PYROSEQUENCING ANALYSIS; ENDODONTIC INFECTIONS; BACTERIAL DIVERSITY; PERIODONTITIS; CHILDREN; IMPACT; MUTANS; FLORA;
D O I
10.3389/fmicb.2014.00508
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The oral microbiome is one of most diversity habitat in the human body and they are closely related with oral health and disease. As the technique developing, high-throughput sequencing has become a popular approach applied for oral microbial analysis. Oral bacterial profiles have been studied to explore the relationship between microbial diversity and oral diseases such as caries and periodontal disease. This review describes the application of high-throughput sequencing for characterization of oral microbiota and analyzing the changes of the microbiome in the states of health or disease. Deep understanding the knowledge of microbiota will pave the way for more effective prevent dentistry and contribute to the development of personalized dental medicine.
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页数:6
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