The role of CD4 T cell help for CD8 CTL activation

被引：82
作者：
Zhang, Sheng [1 ,4 ]
Zhang, Hongjun [2 ]
Zhao, Jiandong [3 ]
机构：
[1] Shanghai Jiao Tong Univ, Peoples Hosp 1, Shanghai 201620, Peoples R China
[2] Qingdao Univ, Med Sch Hosp, Qingdao 266071, Peoples R China
[3] Fudan Univ, Canc Hosp, Dept Radiat Oncol, Shanghai 200433, Peoples R China
[4] Shanghai Key Lab Pancreat Dis, Shanghai, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 384卷 / 04期
关键词：
CD4 T cells; CD8 T cells; Signal pathway; FACTOR FAMILY-MEMBER; DENDRITIC CELLS; IN-VIVO; SECONDARY EXPANSION; CUTTING EDGE; MEMORY; GENERATION; LYMPHOCYTES; TRANCE; IL-12;
D O I：
10.1016/j.bbrc.2009.04.134
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CD4 T cells play an important role in the initiation and persistence of CD8 T cells responses. In this review, we report on and evaluate the mechanisms by which CD4 T cells contribute to activation of CD8 T cells and the signal pathways of the down-streaming events after CD4 T cell help. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：405 / 408
页数：4
相关论文
共 37 条
  • [1] Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation
    Arens, R
    Schepers, K
    Nolte, MA
    van Oosterwijk, MF
    van Lier, RAW
    Schumacher, TNM
    van Oers, MHJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) : 1595 - 1605
  • [2] TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
    Bachmann, MF
    Wong, BR
    Josien, R
    Steinman, RM
    Oxenius, A
    Choi, Y
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) : 1025 - 1031
  • [3] Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    Bennett, SRM
    Carbone, FR
    Karamalis, F
    Flavell, RA
    Miller, JFAP
    Heath, WR
    [J]. NATURE, 1998, 393 (6684) : 478 - 480
  • [4] Helping the CD8+ T-cell response
    Bevan, MJ
    [J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (08) : 595 - 602
  • [5] Bianchi R, 1999, J IMMUNOL, V163, P2517
  • [6] A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    Bourgeois, C
    Rocha, B
    Tanchot, C
    [J]. SCIENCE, 2002, 297 (5589) : 2060 - 2063
  • [7] Buhlmann JE, 1999, J IMMUNOL, V162, P4373
  • [8] Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells
    Bullock, TNJ
    Yagita, H
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (02) : 710 - 717
  • [9] Signal 3 determines tolerance versus full activation of naive CD8 T cells: Dissociating proliferation and development of effector function
    Curtsinger, JM
    Lins, DC
    Mescher, MF
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) : 1141 - 1151
  • [10] In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway
    Diehl, L
    van Mierlo, GJD
    den Boer, AT
    van der Voort, E
    Fransen, M
    van Bostelen, L
    Krimpenfort, P
    Melief, CJM
    Mittler, R
    Toes, REM
    Offringa, R
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (08) : 3755 - 3762
1234